Results 171 to 180 of about 1,319,093 (299)

An enhancement of extrachromosomal circular DNA enrichment and amplification to address the extremely low overlap between replicates. [PDF]

J Biol Chem
Burnham CM, Kurilung A, Wanchai V, Regenberg B, Delgado-Calle J, Basnakian AG, Nookaew I.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Much Ado About Very Little: Some Reflections on ACCC V Berbatis [PDF]

Bond Law Review
Lindsay Trotman, Robert Langton
doaj  

53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination. [PDF]

Sci Adv
Luo S, Zha H, Yang Z, Li S, Yu L, Qiao R, Kong R, Wang Y, Guan J, Zhang X.   +9 more
europepmc   +1 more source

Decomposition of the Little v : Possessors of Interest

Decomposition of the Little v : Possessors of Interest
P(論文) Since the little v was introduced into the Minimalist syntax (Larson 1988, Hale and Keyser 1993, Chomsky 1995: chap.3, Collins 1997, among others), its θ-role assignment mechanism has been frequently discussed. There have been two approaches of dealing with the properties of v: the feature-specification system which leads to four types of v is ...
openaire  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Habitat-Dependent Provisioning Patterns Are Modulated by Weather Conditions in a Rapidly Declining Farmland Raptor. [PDF]

Ecol Evol
Sailas SS, Tschumi M, Grüebler MU, Reipricht F, Stroeken P, van Harxen R, Šálek M.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Dermatology Appointments as an Indicator of Systemic Healthcare Issues. [PDF]

Cureus
Rivera LV, Gonzalez RM, Torres LM, Vazquez-Machado M, Calderon C, Limardo M, Rivera M, Babilonia J, Becemberg A, Sánchez Colón N.   +9 more
europepmc   +1 more source