Results 131 to 140 of about 43,630 (288)

ANTI-TYPHOID VACCINATION WITH ATTENUATED LIVE CULTURES. [PDF]

The Lancet, 1909
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openaire   +2 more sources

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Patent Landscape of Influenza A Virus Prophylactic Vaccines and Related Technologies [PDF]

, 2012
Executive Summary: This report focuses on patent landscape analysis of technologies related to prophylactic vaccines targeting pandemic strains of influenza.
Barton, Jeremy, Cavicchi, Jon R., Janovetz, Jeffrey, Kowalski, Stanley P., Pflugh, David L., Schroeder, John   +5 more
core   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?

Vaccine Research, 2019
Introduction: The global co-circulation of two influenza B virus genetic lineages known as B/Yamagata and B/Victoria may lead to a mismatch between the circulating virus and the strain recommended for use in influenza vaccines.
Irina Kiseleva, Ekaterina Stepanova, Elena Krutikova, Svetlana Donina, Andrey Rekstin, Ekaterina Bazhenova, Maria Pisareva, Anastasia Katelnikova, Kirill Kryshen, Arman Muzhikyan, Elena Grigorieva, Larisa Rudenko   +11 more
doaj  

Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines [PDF]

, 1988
M H Snyder, Robert F. Betts, Dan C. DeBorde, E L Tierney, M L Clements, D A Herrington, S D Sears, Raphael Dolin, H. F. Maassab, Brian R. Murphy   +9 more
openalex   +1 more source

Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions

Advanced Science
Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the
Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin   +3 more
doaj   +1 more source

Development of cold-adapted recombinant live, attenuated influenza A vaccines in the U.S.A. and U.S.S.R. [PDF]

, 1982
Alan P. Kendal, H. F. Maassab, G. I. Alexandrova, Yuri Ghendon   +3 more
openalex   +1 more source