Results 91 to 100 of about 3,792,423 (300)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Care migration from rural Hungary [PDF]
, 2018 szabadon elérhető / Free accessInternational Migration Conference: EU at the crossroads of migration: critical reflections on the ‘refugee crisis’ and new migration deals. Utrecht, Hollandia, 2018.
Váradi, Monika Mária +1 more
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
iMIG: Toward an adaptive live migration method for KVM virtual machines
, 2014 With the energy and power costs increasing alongside the growth of the IT infrastructures, achieving workload concentration and high availability in cloud computing environments is becoming more and more complex. Virtual machine (VM) migration has become
Li, Jianxin +6 more
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Related dirty memory prediction mechanism for live migration in cloud computing systems
, 2013 碩士虛擬化技術能提升雲端運算伺服器的運作效能。而即時轉移(Live Migration)技術主要能使伺服器(Source)發生預設性/災難性狀況時暫時關機，並且把目前伺服器狀態移到其他伺服器(Destination)上，整個過程能讓使用者不會因為目前提供服務的伺服器停止服務而中斷服務。 評估即時轉移的效能指標為停機時間(Downtime)與總轉移時間(Total Migration Time)。其中使用者會感受到使用中的服務被中斷的狀況，為停機時間(Downtime)發生的時候；目前的技術使用預複製轉移(
黃致翔; Huang, Jhih-Siang
core
A Novel Artificial Bee Colony Approach of Live Virtual Machine Migration Policy Using Bayes Theorem
The Scientific World Journal, 2013 Green cloud data center has become a research hotspot of virtualized cloud computing architecture. Since live virtual machine (VM) migration technology is widely used and studied in cloud computing, we have focused on the VM placement selection of live ...
Gaochao Xu +4 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source