Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
EFFECT OF RACCOON (PROCYON LOTOR) REDUCTION ON BLANDING’S TURTLE (EMYDOIDEA BLANDINGII) NEST SUCCESS [PDF]
, 2016 The Lake County Forest Preserve District has monitored a state-endangered Blanding’s Turtle (Emydoidea blandingii) population at two adjoining nature preserves along the Illinois–Wisconsin border since 2004.
Glowacki, Gary A. +2 more
core +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
California Fish and Wildlife JournalLive capture-recapture is often considered the gold standard for estimating wildlife population size or density, but the approach can be limited by permitting requirements, required labor, welfare concerns, and biased estimates resulting from ...
William Tim Bean +5 more
doaj +1 more source
On the Distribution and Fishery Potential of the Japanese Red Crab Chaceon granulatus in the Palauan Archipelago, Western Caroline Islands [PDF]
, 1992 A deep-water trapping survey in the Palauan archipelago, Western Caroline Islands, has revealed an abundance of the Japanese red crab, Chaceon granulatus.
Hastie, L. C., Saunders , W. B.
core
Quantum computation with abelian anyons on the honeycomb lattice [PDF]
, 2005 We consider a two-dimensional spin system that exhibits abelian anyonic excitations. Manipulations of these excitations enable the construction of a quantum computational model.
Pachos, Jiannis K.
core +2 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Invading and expanding: range dynamics and ecological consequences of the greater white-toothed shrew (Crocidura russula) invasion in Ireland. [PDF]
PLoS ONE, 2014 Establishing how invasive species impact upon pre-existing species is a fundamental question in ecology and conservation biology. The greater white-toothed shrew (Crocidura russula) is an invasive species in Ireland that was first recorded in 2007 and ...
Allan D McDevitt +9 more
doaj +1 more source
Rats: an ecologically-based approach for managing a global problem [PDF]
, 2007 Many people have problems with pest rodents. Rats eat our crops, contaminate our stored food, damage our buildings and possessions and spread dangerous diseases to people and livestock.
Belmain, Steven
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