Results 31 to 40 of about 1,818 (235)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Implication of the Niger River Dredging on the Livelihood of Arable Farming Households in Niger State, Nigeria [PDF]

, 2017
Over the years, efforts have been made to improve the living conditions of the rural poor with the government embarking on different projects some of which are questioned even by the intended beneficiaries.
Idowu, R., Opeyemi, G., Adedeji, O.S., Fakayode, S.B., Adenuga, A.H.   +4 more
core   +1 more source

Understanding Herders–Farmers Conflicts in Delta State, Nigeria: A Political Ecology and Livelihoods Vulnerability Perspective

South Sustainability
This research examines the causes of herder-farmer conflicts in Delta State, as well as their socioeconomic impacts and effects on relationships, employing a mixed-methods convergent parallel design. Data were gathered from 396 survey respondents and 30
Obaro Dominic Oghenejabor, Benjamin Evi Benjamin Evi, Malvin Nnamdi Kukaye   +2 more
doaj   +1 more source

Effects of Charcoal Production on Livelihood and Environment in Sapele Local Government Area, Delta State, Nigeria

Tekirdağ Ziraat Fakültesi Dergisi
Economic hardship, poverty, unemployment, and the escalating cost of oil have driven Nigerians to explore diverse avenues for sourcing domestic cooking energy to support their livelihoods. Trade in forest products have significantly influenced livelihood of market participants.
Theophilus Miebi Gbıgbı, Oghenekevwe Abigail Ohwo, Elite Pearl Okpoto   +2 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An Assessment of the Niger Delta Amnesty Programme in Southern Ijaw Local Government Area of Bayelsa State, Nigeria [PDF]

, 2023
The Niger Delta region of Nigeria generates 95% of export earnings and about 40% of the Nigerian government revenue (IMF). This region was known for its calmness and peacefulness until the discovery of oil in the Oloibiri community, Ogbia Local ...
ADEDEJI, Oluwatosin Bethel
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Oil and Security in Nigeria: The Niger Delta Crisis [PDF]

, 2010
This paper examines oil and security in Nigeria, with special reference to the crisis-ravaged Niger Delta. Its focus on the Niger Delta and its festering crisis stems from that region’s critical importance to Nigeria.
Owolabi, O, Okwechime, I, O Owolabi, I Okwechime   +3 more
core   +1 more source

Integrating Long-Term Climate Trend Analysis and Household Socioeconomic Vulnerability to Assess Climate Stress in the Niger Delta Floodplain (Ughelli, Nigeria)

Trends in Ecological and Indoor Environmental Engineering
Background: Climate change increasingly affects livelihoods and socioeconomic stability in climate-vulnerable regions, particularly across Sub-Saharan Africa.
Sylvester Odiana, Onomuvwe Goodness Godwin, Akus Kingsley Okoduwa   +2 more
doaj   +1 more source