Results 141 to 150 of about 155,372 (290)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Hydropower development, resettlement, and urban water security: Evidence from Brazil's Belo Monte Dam. [PDF]
World DevRandell H +3 more
europepmc +1 more source
Extent of Livelihood Assets Influence on Livelihood Changes
International Journal of Current Microbiology and Applied Sciences, 2020 K. Mahandrakumar +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The rural non-farm economy, Livelihoods and their [PDF]
The rural non-farm economy (RNFE) may be defined as comprising all those activities associated with waged work or self-employment in income generating activities (including income in-kind) that are not agricultural but which generate income (including ...
Junior Davis
core
Rethinking rangeland and grassland management for sustaining livelihoods and ecosystem services. [PDF]
Front Plant SciKhanal N.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Gender, Food Security and Livelihoods: The Case of Plan Ghana And Sissala [PDF]
The study was used by Plan International to formulate a common Nutrition Action Plan for its food and nutrition security interventions in developing countries.
Debrah, Kofi, Bediako, J.A.
core
Tradeoffs in climate adaptation? Early data suggest reducing livelihood risks does not change health risks for mobile herders. [PDF]
J Clim Chang HealthPisor AC +6 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source