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Annali italiani di chirurgia, 2000
Acute liver failure is a life-threatening condition since conventional medical treatments have little effect on survival. Artificial liver support systems based on blood detoxification alone have proven to be ineffective. A liver support system should carry out essential functions such as the phase I reaction in which lipid-soluble toxic substance are ...
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Acute liver failure is a life-threatening condition since conventional medical treatments have little effect on survival. Artificial liver support systems based on blood detoxification alone have proven to be ineffective. A liver support system should carry out essential functions such as the phase I reaction in which lipid-soluble toxic substance are ...
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Digestive Diseases and Sciences, 1991
If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attempts have been disappointing.
T, Takahashi, P S, Malchesky, Y, Nosé
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If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attempts have been disappointing.
T, Takahashi, P S, Malchesky, Y, Nosé
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ASAIO Journal, 1995
Whole organ transplantation is the only clinically effective method of treating fulminant hepatic failure and chronic liver failure due to specific genetic, hepatocellular, and anatomic defects of liver function. However, wider application of liver transplantation is limited by shortage of organ donors, high cost, a relatively high morbidity rate, and ...
J, Rozga, A A, Demetriou
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Whole organ transplantation is the only clinically effective method of treating fulminant hepatic failure and chronic liver failure due to specific genetic, hepatocellular, and anatomic defects of liver function. However, wider application of liver transplantation is limited by shortage of organ donors, high cost, a relatively high morbidity rate, and ...
J, Rozga, A A, Demetriou
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Artificial liver support in acute liver failure
European Journal of Gastroenterology & Hepatology, 1999The concept that a bioartificial device could compensate for the loss of hepatic function and thus improve the outcome of acute liver failure (ALF) was first suggested more than three decades ago. Currently, and reflecting renewed interest in this possibility, three such devices are undergoing clinical evaluation.
D J, Dowling, D J, Mutimer
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Artificial Liver and Liver Transplantation
2020The artificial liver support system (ALSS) was first applied to treat acute liver failure in the 1970s with an attempt to replace the detoxification functions of the liver. In the past five decades, a variety of different types of ALSS have been developed to bridge patients with liver failure (LF) to liver transplantation or to support the failing ...
Diyu Chen, Tian Shen, Jian Wu
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Artificial and Bio-Artificial Liver
2016This chapter is focused on the design of artificial liver support devices (LSD). After a short overview of liver functions and pathologies, aimed at defining the minimum requirements for artificial devices, a survey of the different artificial liver support devices developed and used in clinical practice is reported.
Maria Cristina Annesini +3 more
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Nederlands tijdschrift voor geneeskunde, 1998
Despite good results of orthotopic liver transplantation in patients with fulminant hepatic failure the need still exists for an effective and safe artificial liver, able to temporarily take over the complex liver function so as to bridge the gap with transplantation or regeneration.
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Despite good results of orthotopic liver transplantation in patients with fulminant hepatic failure the need still exists for an effective and safe artificial liver, able to temporarily take over the complex liver function so as to bridge the gap with transplantation or regeneration.
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Clinical and investigative medicine. Medecine clinique et experimentale, 1997
Without adequate liver function, the body is unable to sustain several vital metabolic functions, such as energy supply, acid-base balance and thermoregulation. Whereas the clinical picture of chronic liver failure is often dominated by portal hypertension, fulminant hepatic failure (FHF) is typically characterized by an acute metabolic deficit ...
N L, Sussman, J H, Kelly
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Without adequate liver function, the body is unable to sustain several vital metabolic functions, such as energy supply, acid-base balance and thermoregulation. Whereas the clinical picture of chronic liver failure is often dominated by portal hypertension, fulminant hepatic failure (FHF) is typically characterized by an acute metabolic deficit ...
N L, Sussman, J H, Kelly
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