Results 101 to 110 of about 72,056 (263)

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Characteristics of Adverse Effects in Patients with Chronic Alcoholic Pancreatitis and Concomitant Alcoholic Liver Cirrhosis Child-Pugh Class A and B

Galician Medical Journal, 2016
Alcohol intoxication is the third leading cause of death, and among alcohol-dependent patients alcohol-related pathology (alcoholic liver disease, acute and chronic pancreatitis, cardiomyopathy, polyneuro-encephalopathy) accounts for 42.6% of fatal cases.
K. M. Skoropad, V. H. Mishchuk
doaj  

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Pilot implementation and evaluation of a social risk screening tool for hospitalised patients in Singapore

Journal of Hospital Medicine, EarlyView.
Abstract Background Routine in‐hospital screening of social risk factors linked with poor health outcomes is not done in Singapore, where an aging population pays for 25% healthcare costs out‐of‐pocket despite universal coverage. Objective We developed and implemented a social risk screening tool for hospitalised patients and reported the association ...
Orlanda Q. M. Goh, Poh Yong Tan, Tse Yean Teo, Rachel Peh, Jeanne Ng, Aaron Chua, Xuling Lin, Tharmmambal Balakrishnan, Nicholas Graves, Mei Ling Kang, Xiaohui Xin   +10 more
wiley   +1 more source

Alcoholic Cirrhosis of the Liver [PDF]

BMJ, 1896
openaire   +2 more sources

Chronic Liver Disease: Assessing Inflammation and Fibrosis Using Three‐Dimensional MR Elastography With Same‐Day Biopsy in a Prospective Cohort

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Three‐dimensional (3D) MR elastography (MRE) derives viscoelastic parameters that may reflect inflammation, but their frequency dependence and the influence of steatosis on inflammation grading and fibrosis staging remain unclear. Purpose To investigate 3D multifrequency MRE for assessing hepatic inflammation, fibrosis stage across ...
Shan Cai, Christian Simonsson, Markus Karlsson, Wile Balkhed, Jens Tellman, Simone Ignatova, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Wolf C. Bartholomä, Nils Dahlström, Peter Lundberg   +11 more
wiley   +1 more source

Association between specialized nutrition support and 90‐day mortality relative to standard of care in malnourished adults with decompensated cirrhosis: A retrospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Malnutrition is common among patients with decompensated liver cirrhosis and linked to poor prognosis. Guidelines recommend intensified nutrition support e.g. parenteral nutrition, but evidence regarding safety and effectiveness is scarce. We aimed to investigate the impact of nutrition support, specifically parenteral nutrition, on
Katharina L. Hupa‐Breier, Laura Buttler, Claudia Seipt, Andrea Markowski, Marie Griemsmann, Tammo L. Tergast, Birgit Kaufmann, Hannah Rieland, Heiner Wedemeyer, Benjamin Maasoumy, Andrea Schneider   +10 more
wiley   +1 more source

Liver disease in Shwachman‐Diamond syndrome: A comprehensive characterization across the age spectrum

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Shwachman‐Diamond syndrome (SDS) is an inherited bone marrow failure disorder, and its hepatic phenotype is poorly defined. Our objective was to systematically characterize the prevalence, features, and outcomes of liver injury in a multicenter SDS cohort. Methods Retrospective registry study of 171 patients with biallelic Shwachman‐
Jane Koo, Diana Schwarz, Meghan Haney, Juan Putra, Jaeson Kim, Leah Cheng, Elizabeth Korn, Sarah Steltz, Lois Schwarz, Sara Loveless, Richard Cooper, Claire Dusa, Adam Lane, Kasiani C. Myers, Akiko Shimamura, Amit S. Grover, Andrew Wehrman   +16 more
wiley   +1 more source

Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents.
Zu‐Yau Lin, Ming‐Lun Yeh, Po‐Cheng Liang, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang   +8 more
wiley   +1 more source