Results 241 to 250 of about 120,185 (315)

Mechanistic insights into atorvastatin-induced hepatotoxicity: molecular pathways, clinical relevance, and strategies for safer personalized therapy. [PDF]

Clin Exp Med
Abdel-Rasol MA, El-Sayed WM.
europepmc   +1 more source

Severe Thrombocytopenia Is Associated With Bleeding in Hepatocellular Carcinoma Patients Receiving Antiangiogenic Therapy

Portal Hypertension &Cirrhosis, EarlyView.
Thrombocytopenia is common in hepatocellular carcinoma and may increase bleeding risk during antiangiogenic therapy, yet the clinically relevant platelet threshold remains uncertain. We found that a baseline platelet count < 50 × 109/L was associated with bleeding; patients below this cutoff had a substantially higher bleeding rate than those with ...
Jun Tie, Zhengcai Liu, Xulong Yuan, Kai Li, Jing Niu, Jiao Xu, Li Xu, Yongquan Shi, Shuqiang Yue   +8 more
wiley   +1 more source

Hepatitis D Virus Pathogenesis: A Sense of Complications. [PDF]

Viruses
Haennel Y, Baumert TF, Lupberger J.
europepmc   +1 more source

Sono‐Vasomics With Super‐Resolution Contrast‐Enhanced Ultrasound (SR‐CEUS) for Characterization of Focal Liver Lesions: A Case Report

Portal Hypertension &Cirrhosis, EarlyView.
ABSTRACT Accurate differentiation between benign and malignant focal liver lesions (FLLs) remains a major diagnostic challenge. Vasomics, an emerging discipline, classifies vascular phenotypes into anatomical, biomechanical, biochemical, pathophysiological, and composite categories. Sono‐Vasomics, the ultrasound‐based subset, leverages super‐resolution
Yijie Qiu, Ying Wang, Rui Cheng, Ruiling He, Yi Dong, Christoph F. Dietrich   +5 more
wiley   +1 more source

Single-cell atlas of hepatic cellular plasticity and immune niche reprogramming in liver cirrhosis. [PDF]

J Transl Med
Zhang Q, Zhou N, Kan X, Zhang Z, Fang Y, Liu H, Chen Y.   +6 more
europepmc   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

GATA2 deficiency exacerbates chronic liver injury <i>via</i> disrupting hepatocyte death-regeneration balance: Clinical, histopathological, and molecular evidence. [PDF]

World J Stem Cells
Chen YF, Li SQ, Zhang J, Ma WT, Zhou Y, Rao JX, Yi Y, Cheng QJ, Zhong WW, Chen H, Chen YH, Luo YW, He YH.   +12 more
europepmc   +1 more source

Matrix Viscoelasticity: The Overlooked Architect of Solid Tumour Evolution

Organ Medicine, EarlyView.
Ruixi Huang, Yupeng Guan
wiley   +1 more source

Comparable Diagnostic Accuracy but Discordant Thresholds Between FibroTouch and FibroScan: A Biopsy‐Based Comparative Study

Portal Hypertension &Cirrhosis, EarlyView.
In this biopsy‐controlled study, FibroTouch and FibroScan demonstrated comparable diagnostic accuracy for liver fibrosis staging (AUROCs > 0.900), but FibroTouch required consistently higher stiffness thresholds. These discrepancies were more pronounced in patients with MAFLD, highlighting the need for device‐specific cutoffs to avoid misclassification.
Min Wang, You Deng, Guanhua Zhang, Xinyan Zhao, Xiaoming Wang, Xiaojuan Ou, Min Li, Hong Ma, Yu Wang   +8 more
wiley   +1 more source

Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. [PDF]

World J Clin Cases
Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN.   +9 more
europepmc   +1 more source