Results 121 to 130 of about 12,541,927 (431)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Heterogeneity‐induced NGF‐NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti‐tumor immunotherapy with PD‐1 mAb in hepatocellular carcinoma

Cancer Medicine
Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset of hepatocellular carcinoma patients (GSE149614) for cell ...
Xin Wang, Tongwang Yang, Shangheng Shi, Chuanshen Xu, Feng Wang, Deshu Dai, Ge Guan, Yong Zhang, Shuxian Wang, Jianhong Wang, Bingliang Zhang, Peng Liu, Xiaoshuai Bai, Yan Jin, Xinqiang Li, Cunle Zhu, Dexi Chen, Qingguo Xu, Yuan Guo   +18 more
doaj   +1 more source

Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitro

Virology Journal, 2020
Background Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy.
Jie Ruan, Shuo Sun, Xin Cheng, Pengyu Han, Yinge Zhang, Dianxing Sun   +5 more
doaj   +1 more source

Eleven immune-gene pairs signature associated with TP53 predicting the overall survival of gastric cancer: a retrospective analysis of large sample and multicenter from public database

Journal of Translational Medicine, 2021
Background Growing attention have been paid to the relationship between TP53 and tumor immunophenotype, but there are still lacking enough search on the field of gastric cancer (GC).
Junyu Huo, Liqun Wu, Yunjin Zang
doaj   +1 more source

Latent class mixed modelling for phenotypic stratification of primary biliary cholangitis patients on first line treatment [PDF]

arXiv, 2022
In patients with primary biliary cholangitis (PBC), the serum liver biochemistry measured during treatment with ursodeoxycholic acid (the UDCA response) accurately predicts long-term outcome. In this study we sought to use liver biochemistry, and in particular alkaline phosphatase (ALP), as a surrogate marker of disease activity, for phenotypic ...
arxiv  

Nonalcoholic fatty liver disease: a systematic review.

Journal of the American Medical Association (JAMA), 2015
IMPORTANCE Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis affect approximately 30% and 5%, respectively, of the US population.
M. Rinella
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

A novel imaging index for predicting adverse progression in acute-on-chronic liver failure related to hepatitis B virus: the low erector spine index

BMC Gastroenterology, 2023
Background It is widely known that muscle mass influences the outcomes of many chronic diseases. Erector spine mass is a convenient parameter obtained from routine abdominal computed tomography (CT).
Chao Zhou, Yuan Liu, Xiaoxiao Liang, Ning Zhang, Tingting He, Jingjing Zhang, Jin Zhang, Shuangnan Fu, Xin Li, Pengcheng Liu, Tianyi Zhang, Man Gong   +11 more
doaj   +1 more source

Exploiting full Resolution Feature Context for Liver Tumor and Vessel Segmentation via Integrate Framework: Application to Liver Tumor and Vessel 3D Reconstruction under embedded microprocessor [PDF]

arXiv, 2021
Liver cancer is one of the most common malignant diseases in the world. Segmentation and labeling of liver tumors and blood vessels in CT images can provide convenience for doctors in liver tumor diagnosis and surgical intervention. In the past decades, many state-of-the-art medical image segmentation algorithms appeared during this period.
arxiv  

Clinical applications of squamous cell carcinoma antigen-immunoglobulins M to monitor chronic hepatitis C [PDF]

, 2015
Hepatitis C virus (HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma (HCC), one of the most common fatal cancers worldwide - fourth for ...
Fassina, Giorgio, Gallotta, Andrea, MARTINI, ANDREA, PONTISSO, PATRIZIA   +3 more
core   +1 more source