Results 121 to 130 of about 7,045,458 (313)

Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents

, 2008
Background. Visceral adiposity is the major risk factor for paediatric nonalcoholic fatty liver disease. Aims. Determine the prevalence of nonalcoholic fatty liver disease according to the visceral fat quartile. Subjects.
Prado, Wagner Luiz do [UNIFESP], Piano, Aline de [UNIFESP], Mello, Marco Tulio de [UNIFESP], Caranti, Danielle Arisa [UNIFESP], Lofrano-Prado, Mara Cristina [UNIFESP], Cristofalo, Dejaldo J. M. [UNIFESP], Lederman, Henrique Manoel [UNIFESP], Tufik, Sergio [UNIFESP], Carnier, June [UNIFESP], Dâmaso, Ana Raimunda [UNIFESP], Tock, Lian [UNIFESP]   +10 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease

, 2014
Background/Aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score ...
YILMAZ, YUSUF
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Serum osteopontin levels as a predictor of portal inflammation in patients with nonalcoholic fatty liver disease

, 2013
Background: Osteopontin is a secreted phosphorylated glycoprotein that is expressed by a variety of cell types and that mediates numerous and diverse biological functions. Osteopontin knockout mice are protected from obesity-induced hepatic steatosis. In
ÖZEN ALAHDAB, YEŞİM, ATUĞ, ÖZLEN, EREN, FATİH, YILMAZ, YUSUF   +3 more
core   +1 more source

Aging and Chronic Liver Disease.

, 2020
Aging increases the incidence of chronic liver disease (CLD), worsens its prognosis, and represents the predominant risk factor for its development at all different stages.
Gracia Sancho, Jorge Sergio, Maeso-Díaz, Raquel   +1 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Transarterial Chemoembolization Combined with Regorafenib and PD-1 Inhibitor as Second-Line Therapy for Unresectable Hepatocellular Carcinoma

Cancer Management and Research
Di Wang,1,* Wei Zhang,2,* Xudong Gao,2 Huifang Kong,2 Huixin Zhang,2 Jiagan Huang,2 Meng Zhang,1 Xiujuan Chang,2 Zhen Zeng1,2 1 302 Clinical Medical School, Peking University, Beijing, People’s Republic of China; 2Senior Department of ...
Wang D, Zhang W, Gao X, Kong H, Zhang H, Huang J, Zhang M, Chang X, Zeng Z   +8 more
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