Results 41 to 50 of about 2,535,651 (215)

Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP

open access: yesTranslational Oncology, 2016
Background: The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor.
Jing Liu   +9 more
doaj   +1 more source

Disease recurrence and rejection following liver transplantation for autoimmune chronic active liver disease [PDF]

open access: yes, 1992
Autoimmune chronic active liver disease (ACALD), a major indication for liver transplantation, is associated strongly with antigenic determinants HLA-B8 and DR3.
Block, GD   +6 more
core   +1 more source

Role of liensinine in sensitivity of activated macrophages to ferroptosis and in acute liver injury

open access: yesCell Death Discovery, 2023
Acute liver injury (ALI) is an acute inflammatory liver disease with a high mortality rate. Alternatively, activated macrophages (AAMs) have been linked to the inflammation and recovery of ALI.
Jing Li   +12 more
doaj   +1 more source

Animal models of NASH: getting both pathology and metabolic context right [PDF]

open access: yes, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core   +1 more source

Housing-temperature reveals energy intake counter-balances energy expenditure in normal-weight, but not diet-induced obese, male mice

open access: yesCommunications Biology, 2022
The impact of ambient housing temperature on the interaction of energy intake, energy expenditure and glycemic control in normal and diet-induced obese mice is examined.
Linu Mary John   +6 more
doaj   +1 more source

Study on the Retreatment, Outcome, and Potential Predictors of Recurrence in Patients With Recurrence of Hepatitis B After Functional Cure

open access: yesFrontiers in Immunology, 2022
BackgroundStudies about the retreatment and predictors for patients with hepatitis B recurrence after functional cure are rare. This study aimed to evaluate the effect of retreatment, outcome, and potential predictors of recurrence in patients with ...
Xiao Lin   +10 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

open access: yes, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence   +2 more
core   +2 more sources

Polycystic liver disease [PDF]

open access: yesBMJ Case Reports, 2014
A widespread use of ultrasound (US) examination is contributing to an increase in the diagnosis of renal and hepatic cysts. However, the vast majority of these lesions are benign with an indolent course during the patient's lifespan. Adult polycystic kidney disease (APKD) is one of the most common diagnosed entities.
Rodrigo Nazário, Leão   +2 more
openaire   +2 more sources

Serum hepatitis B virus large and medium surface proteins as novel tools for predicting HBsAg clearance

open access: yesFrontiers in Immunology, 2022
BackgroundThere is still lack of reliable predictors for hepatitis B surface antigen (HBsAg) clearance. Recent studies have shown that the levels of large (LHBs) and medium hepatitis B surface proteins (MHBs) are closely related to antiviral efficacy ...
Xiao Lin   +10 more
doaj   +1 more source

Endothelial dysfunction in adolescents and young adults with nonalcoholic liver disease [PDF]

open access: yes, 2019
Nonalcoholic liver disease is a global public health problem that increases cardiovascular morbidity and mortality in these patients. This paper discusses endothelial dysfunction among patients (adolescents and young adults) with nonalcoholic liver ...
Donoiu, Ionuț   +6 more
core   +1 more source

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