Results 121 to 130 of about 1,327,541 (308)

LOX-1 rewires glutamine ammonia metabolism to drive liver fibrosis

Molecular Metabolism
Objective: Liver fibrosis is a crucial condition for evaluating the prognosis of chronic liver disease. Lectin-1ike oxidized low density lipoprotein receptor-1 (LOX-1) has been shown potential research value and therapeutic targeting possibilities in ...
Ruihua Huang, Hanyu Cui, Mohammed Abdulaziz Yahya Ali Alshami, Chuankui Fu, Wei Jiang, Mingyuan Cai, Shuhan Zhou, Xiaoyun Zhu, Changping Hu   +8 more
doaj   +1 more source

Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease [PDF]

, 2011
Approximately 5–10% of cystic fibrosis (CF) patients develop multilobular cirrhosis during the first decade of life. Most CF patients later develop signs of portal hypertension with complications, mainly variceal bleeding.
Houwen, R, Carla Colombo, Debray, Dominique, Strandvik, Birgitta, B. Strandvik, Deirdre Kelly, Colombo, C, Kelly, Deirdre, D. Debray, C. Colombo, Dominique Debray, R. Houwen, Roderick Houwen, Strandvik, Birgitta,, D. Kelly, Kelly, D, Birgitta Strandvik, Colombo, Carla, Houwen, Roderick, Strandvik, B,, Debray, D   +20 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Periplakin Attenuates Liver Fibrosis via Reprogramming CD44Low Cells into CD44High Liver Progenitor CellsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Liver progenitor cells (LPCs) contribute significantly to the restoration of injured liver parenchyma and promote liver regeneration, thereby ameliorating liver fibrosis.
Lichao Zhang, Zhiyong Xiong, Zebin Chen, Meiyining Xu, Siyu Zhao, Xianzhi Liu, Kefeng Jiang, Yunyi Hu, Shurui Liu, Xi Sun, Zhongdao Wu, Jia Shen, Lifu F. Wang   +12 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Regulation of the synthesis of tissue inhibitors of metalloproteinase-1 and -2 by hepatic and pancreatic stellate cells

, 2010
Hepatic stellate cells (HSC) play a central role in fibrosis development by production of extracellular matrix and also by secretion of matrix metalloproteinases (MMPs) and Tissue inhibitors of metalloproteinases (TIMPs) including TIMP-2 and MMP-2.
McCrudden, Peter Raymond
core   +1 more source

Magnetic Resonance Elastography for Staging Liver Fibrosis in the Oncopig

Diagnostics
This pilot study investigated the feasibility of using magnetic resonance elastography (MRE) for the non-invasive detection and quantification of liver fibrosis in the Oncopig cancer model.
Ron C. Gaba, Lobna Elkhadragy, Thomas Pennix, Kyle M. Schachtschneider, Courtni R. Bolt, Aaron Anderson, Shreyan Majumdar, Denise Weber, Herbert E. Whiteley, Daniel P. Regan, Lawrence B. Schook, Bradley P. Sutton   +11 more
doaj   +1 more source

Liver transplant in cystic fibrosis: a poll among European centers. A study from the European Liver Transplant Registry

, 2006
Liver Transplant (LTx) has been rarely performed in cystic fibrosis (CF) patients and indications and outcomes are not well defined. A questionnaire was sent to all European CF and LTx centers to collect data on CF transplanted patients.
European Cystic Fibrosis Society, P. De Lorenzo, B.M. Assael for the EGSLTCF and on behalf of the European Liver Transplant Association (ELTA) and European Cystic Fibrosis Society, J. Manzanares, M. G. Valsecchi, R. Adam, on behalf of the European Liver Transplant Association, M. L. Melzi, C. Colombo, M. Colledan, B. Gridelli, D. A. Kelly, M. Strazzabosco, P. Jara   +13 more
core   +1 more source

How big a problem is non-alcoholic fatty liver disease? [PDF]

, 2011
This is one of a series of occasional articles that highlight areas of practice where management lacks convincing supporting ...
McPherson, Stuart, Anstee, Quentin M, S. McPherson, Q. M. Anstee, Day, Christopher P, C. P. Day   +5 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source