Results 271 to 280 of about 491,008 (310)
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Seminars in Liver Disease, 2009
Alcoholic liver disease involves significant crosstalk among intracellular signaling events in the liver. Overall, inflammatory and innate immune responses in Kupffer cells due to elevated gut-derived plasma endotoxin levels, increased reactive oxygen species-induced damage, and profibrogenic factors such as acetaldehyde or lipid peroxidation products ...
Francisco Javier, Cubero +2 more
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Alcoholic liver disease involves significant crosstalk among intracellular signaling events in the liver. Overall, inflammatory and innate immune responses in Kupffer cells due to elevated gut-derived plasma endotoxin levels, increased reactive oxygen species-induced damage, and profibrogenic factors such as acetaldehyde or lipid peroxidation products ...
Francisco Javier, Cubero +2 more
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Clinica Chimica Acta, 2006
Liver fibrosis represents a significant health problem worldwide of which no acceptable therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I collagen. A great deal of research has been performed to understand the molecular mechanisms responsible for the development of liver fibrosis.
Shigeki, Tsukada +2 more
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Liver fibrosis represents a significant health problem worldwide of which no acceptable therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I collagen. A great deal of research has been performed to understand the molecular mechanisms responsible for the development of liver fibrosis.
Shigeki, Tsukada +2 more
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Pathophysiology of Liver Fibrosis
Digestive Diseases, 2015Progressive accumulation of fibrillar extracellular matrix (ECM) in the liver is the consequence of reiterated liver tissue damage due to infective (mostly hepatitis B and C viruses), toxic/drug-induced, metabolic and autoimmune causes, and the relative chronic activation of the wound-healing reaction. The process may result in clinically evident liver
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Gastroenterology Clinics of North America, 2019
All chronic liver disease can lead to liver fibrosis. Assessment of the severity of liver fibrosis is central to making treatment and management decisions. Liver biopsy, the gold standard for liver fibrosis assessment, is invasive and carries risks of complications and sampling errors.
Michelle, Lai, Nezam H, Afdhal
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All chronic liver disease can lead to liver fibrosis. Assessment of the severity of liver fibrosis is central to making treatment and management decisions. Liver biopsy, the gold standard for liver fibrosis assessment, is invasive and carries risks of complications and sampling errors.
Michelle, Lai, Nezam H, Afdhal
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Clinica Chimica Acta, 2012
Autotaxin (ATX) hydrolyzes lysophosphatidylcholine to produce lysophosphatidic acid (LPA), a multi-functional bioactive lipid mediator. ATX is a major determinant of LPA levels in the blood, and the pathophysiological functions of ATX are thought to be largely attributed to its ability to produce LPA.
Hitoshi, Ikeda, Yutaka, Yatomi
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Autotaxin (ATX) hydrolyzes lysophosphatidylcholine to produce lysophosphatidic acid (LPA), a multi-functional bioactive lipid mediator. ATX is a major determinant of LPA levels in the blood, and the pathophysiological functions of ATX are thought to be largely attributed to its ability to produce LPA.
Hitoshi, Ikeda, Yutaka, Yatomi
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Seminars in Liver Disease, 2017
AbstractLiver fibrosis is a common consequence of chronic liver injury and is a key determinant of liver-associated morbidity and mortality. Identification of new mechanisms of fibrosis, including disease-specific molecular drivers, remains relevant to reveal novel biomarkers and therapeutic targets.
Veronica, Massey +2 more
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AbstractLiver fibrosis is a common consequence of chronic liver injury and is a key determinant of liver-associated morbidity and mortality. Identification of new mechanisms of fibrosis, including disease-specific molecular drivers, remains relevant to reveal novel biomarkers and therapeutic targets.
Veronica, Massey +2 more
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Liver Fibrosis in Alcoholic Liver Disease
Seminars in Liver Disease, 2015Excessive alcohol consumption causes a wide spectrum of liver disease, ranging from simple steatosis to severe forms of liver injury such as steatohepatitis, liver fibrosis, cirrhosis, and liver cancer. Moreover, alcohol consumption also accelerates liver fibrosis in patients with other types of liver diseases such as viral hepatitis and nonalcoholic ...
Ramon, Bataller, Bin, Gao
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Liver fibrosis in paediatric liver diseases
Best Practice & Research Clinical Gastroenterology, 2011Numerous paediatric liver diseases from different origins may be complicated by development of liver fibrosis and progression to cirrhosis. Although fibrogenesis, which represents a major driving force for the development of liver fibrosis, has common tracts whatever the aetiology, liver fibrosis has different histopathological patterns in paediatric ...
Alisi A, de Vito R, Monti L, Nobili V.
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Journal of Gastroenterology and Hepatology, 2011
AbstractFibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease. Blood‐based biomarkers offer a number of advantages over the traditional standard of fibrosis assessment of liver biopsy, including safety, cost‐savings and wide spread accessibility.
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AbstractFibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease. Blood‐based biomarkers offer a number of advantages over the traditional standard of fibrosis assessment of liver biopsy, including safety, cost‐savings and wide spread accessibility.
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2013
Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. Liver fibrosis is now known to be a dynamic process having significant potential for resolution. Therefore, fibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease.
Ki Tae, Suk +3 more
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Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. Liver fibrosis is now known to be a dynamic process having significant potential for resolution. Therefore, fibrosis prediction is an essential part of the assessment and management of patients with chronic liver disease.
Ki Tae, Suk +3 more
openaire +2 more sources