Results 131 to 140 of about 2,306,483 (343)

Microsphere Strategy to Generate Conformal Bone Organoid Units with Osteoimmunomodulation and Sustainable Oxygen Supply for Bone Regeneration

Advanced Science, EarlyView.
Oxygen‐releasing immunomodulatory microspheres are used to construct conformal bone organoid units that enhance osteogenesis, angiogenesis, and immune regulation. By integrating BMSCs, macrophages, and CaO₂‐HAp into a SilMA‐based hydrogel platform, this strategy provides sustained oxygen supply and anti‐inflammatory microenvironments, leading to ...
Anfu Deng, Hao Zhang, Yan Hu, Jilong Li, Jian Wang, Xiao Chen, Zhen Geng, Ke Xu, Yuxiao Lai, Jianhua Wang, Yingying Jing, Long Bai, Jiacan Su   +12 more
wiley   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Multiple Adenoma (Hamartoma) of the Liver Treated by Subtotal (90%) Resection:*

, 1964
Anthony P. Monaco, Jónas Hallgrímsson, William V. McDermott   +2 more
openalex   +2 more sources

Can determination of the proliferative capacity of the nontumor portion predict the risk of tumor recurrence in the liver remnant after resection of human hepatocellular carcinoma? [PDF]

, 1993
Jen‐Hwey Chiu, Li‐Hwa Wu, Hwa-Li Kao, Hwey-May Chang, Shyh‐Haw Tsay, Che‐Chuan Loong, Gar-Yang Cha, Wing‐Yu Lui   +7 more
openalex   +1 more source

Advanced Liver Resection [PDF]

Digestive Surgery, 2011
Thomas M. van Gulik, Jan Schmidt
openaire   +3 more sources

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

Hepatic Resection for Massive Liver Injuries

, 1963
Ernest Poulos
openalex   +2 more sources

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

A CASE OF ADVANCED POLYNEUROPATHY ASSOCIATED WITH MULTIPLE INTESTINAL DIVERTICULOSIS, FATTY LIVER CIRRHOSIS AND MALNUTRITION FOLLOWING GASTRIC RESECTION (BII METHOD)

, 1978
Hideki KOH, Akira Tanaka, Yuji Hashimoto, Nobuhisa Azegami, Masataka Arita, Hiroshi Murase, Toshiaki Sunaga, Fujío Numano, Hidenori MAEZAWA, Kimiharu YOSHIMINE, Osamu Matsubara, Shigeru Hatakeyama   +11 more
openalex   +2 more sources

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source