Results 191 to 200 of about 325,306 (358)

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

The value of tranexamic acid in liver resection should not be exaggerated or ignored. [PDF]

Hepatobiliary Surg Nutr
Ge P, Wu Y.
europepmc   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Hypothermic oxygenated machine perfusion for <i>ante-situm</i> liver resection: a note of caution? [PDF]

Hepatobiliary Surg Nutr
Aini A, Azoulay D, Dong J.
europepmc   +1 more source

Extended liver resection [PDF]

HPB, 2016
I.I. Dzidzava, S.A. Soldatov, B.N. Kotiv, A.V. Slobodyanik, D.P. Kashkin   +4 more
openaire   +2 more sources

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

Advanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng, Željko Janićijević, Liliana R. Loureiro, Lydia Hoffmann, Poh Soo Lee, Isli Cela, Benjamin Kruppke, Alexandra Kegler, Anja Feldmann, Ielizaveta Gorodetska, Anja Madleine Markl, Anna Dubrovska, Anne Kathrin Offermann, Michael Bachmann, Larysa Baraban   +14 more
wiley   +1 more source

Comparative outcomes of combined thermal ablation and liver resection versus liver resection alone for multiple colorectal liver metastases: a systematic review and meta-analysis. [PDF]

Front Oncol
Meng Z, Li B, Zhou C, Cao L, Zhang J, Feng J, Wang G.   +6 more
europepmc   +1 more source

Water-Soluble Ethylhydroxyethyl Cellulose Prevents Bacterial Translocation Induced by Major Liver Resection in the Rat

, 1993
Xiangdong Wang, Roland Andersson, Vasile Soltesz, Weidun Alan Guo, Stig Bengmark   +4 more
openalex   +2 more sources

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Management of bilioenteric anastomosis leakage after major liver resection. [PDF]

BJS Open
Abbasi Dezfouli S, Heidenreich E, Shahrbaf M, Khajeh E, Chang DH, Klauss M, Mieth M, Loos M, Büchler M, Mehrabi A.   +9 more
europepmc   +1 more source