Results 61 to 70 of about 2,386,823 (356)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Metachronous liver metastasis after curative gastrectomy for gastric adenocarcinoma [PDF]

Korean Journal of Clinical Oncology, 2014
Purpose: The prognosis of patients with liver metastasis from gastric cancer is poor and the optimal treatment remains undetermined. This study identified prognostic factors for survival of patients with metachronous liver metastasis with no other ...
Suk-Hyun Shin, Jong Man Kim, Su Mi Kim, Min-Gew Choi, Choon Hyuck David Kwon, Jae-Won Joh, Sung Kim, Suk-Koo Lee, Cheol Keun Park   +8 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Role of Surgical Approach to Synchronous Colorectal Liver Metastases: A Retrospective Analysis

Cancer Management and Research, 2021
Shengyong Zhai,1,* Xiaojing Sun,2,* Longfeng Du,1 Kai Chen,1 Shanshan Zhang,2 Yiran Shi,1 Fei Yuan1 1Department of Oncology Surgery, Weifang People’ s Hospital, Weifang Medical College, Weifang City, Shandong Province, 261041, People’s ...
Zhai S, Sun X, Du L, Chen K, Zhang S, Shi Y, Yuan F   +6 more
doaj  

Role and limitation of neoadjuvant hepatic arterial infusion chemotherapy in advanced hepatocelluar carcinoma patients with Child-Pugh class A

World Journal of Surgical Oncology, 2019
Background Patients with advanced hepatocellular carcinoma (HCC) have a poor oncologic outcome. In this study, we evaluated the role and limitation of neoadjuvant hepatic arterial infusion chemotherapy (HAIC) in advanced HCC patients with Child-Pugh ...
Beom-Hui Lee, Dong-Shik Lee, Chan Woo Cho, Sung-Su Yun   +3 more
doaj   +1 more source

The effect of routine lymphadenectomy of the hepatic basin on the duration of the liver resection due to colorectal carcinoma metastases [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. Today, lymphatic metastases are only a relative contraindication for the surgical treatment of colorectal carcinoma (CRC). The aim of this study was to evaluate the effect of routine lymphadenectomy of the hepatic basin on the duration of
Basarić Dragan D., Soldatović Ivan, Lekić Nebojša, Đorđević Vladimir, Đurašić Ljubomir, Micev Marjan   +5 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Influence of endovascular preparation on results of surgical treatment of liver through hemangoma

Ендоваскулярна нейрорентгенохірургія, 2018
Objective – to study the effectiveness of preoperative portal vein branches embolization (PVE) in patients with advanced liver hemangiomas in the complex of preparation of these patients for radical liver resection. Materials and methods.
V.A. Kondratyuk, S.M. Furkalo, O.A. Vlasenko, O.O. Pustyntsev   +3 more
doaj   +1 more source

Prognostic Value of CD8+ Lymphocytes in Hepatocellular Carcinoma and Perineoplastic Parenchyma Assessed by Interface Density Profiles in Liver Resection Samples [PDF]

, 2023
Rokas Stulpinas, Dovile Zilenaite-Petrulaitiene, Allan G. Rasmusson, Aistė Gulla, Agnė Grigonytė, Kęstutis Strupas, Arvydas Laurinavičius   +6 more
openalex   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source