Results 141 to 150 of about 97,066 (261)

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

open access: yesiMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang   +16 more
wiley   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

open access: yesiMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li   +7 more
wiley   +1 more source

A uterine‐centric view of reproductive senescence: Genetic insights into late‐life performance in laying hens

open access: yesiMetaOmics, EarlyView.
This study identifies uterus weight as a heritable (h2 = 0.45) intermediate phenotype that independently associates with late‐life egg production and eggshell quality in aged laying hens. Genome‐wide association study (GWAS) reveals a genome‐wide significant locus on chromosome 3 and suggestive loci on chromosome 11 for uterus weight, mediation ...
Junnan Zhang   +7 more
wiley   +1 more source

Climate change amplifies global mycotoxin exposure: Emerging risks and sustainable solutions

open access: yesiMetaOmics, EarlyView.
Climate change intensifies mycotoxin contamination through rising temperatures, elevated CO2, and altered precipitation. Global surveys reveal a high and widespread prevalence of major mycotoxins in staple cereals, with low‐income countries bearing the greatest burden.
Mengyao Xue   +8 more
wiley   +1 more source

Microbial DNA methylation links rumen transcriptional activity to methane emission divergence in dairy cows

open access: yesiMeta, EarlyView.
Genome‐resolved methylomics uncovers the first DNA methylation atlas of the dairy cow rumen microbiome. Microbial DNA methylation profiles diverge between low‐ and high‐ methane‐emitting dairy cows despite limited taxonomic differences. Differential methylation is linked to transcriptional variation in genes involved in carbon metabolism, hydrogen ...
Xinyue Zhang   +9 more
wiley   +1 more source

Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara   +4 more
wiley   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol   +4 more
wiley   +1 more source

The Art of Reception: Field Visits as Microcosms for Development Interventions of Non‐Governmental Organisations in Uganda

open access: yesJournal of International Development, EarlyView.
ABSTRACT Field visits are common phenomena with non‐governmental organisations in Uganda. During these visits, Ugandan national staff guide visitors on series of meetings and interactions in the field. Following an actor‐oriented approach and drawing on ethnographic data on 14 field visits, this paper understands the field visit as a microcosm for the ...
Caspar Edward Swinkels
wiley   +1 more source

Nutrient composition and heavy metal accumulation in water hyacinth [Eichhornia crassipes (Mart.) Solms] and water lettuce (Pistia stratiotes L.) from the Dande River, Nepal: Implications for use as alternative feed resources

open access: yesJSFA reports, EarlyView.
Abstract Background The proliferation of invasive aquatic macrophytes poses a significant ecological challenge globally, while many tropical regions face chronic shortages of affordable livestock feed. This study addresses this dual problem by assessing two invasive species, water hyacinth (Eichhornia crassipes) and water lettuce (Pistia stratiotes ...
Anish Balchhaudi   +5 more
wiley   +1 more source

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