Results 91 to 100 of about 5,215 (215)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Association between living alone and frailty, and its gender disparity: a multicenter cross-sectional study in Chinese older adults undergoing hospitalisation

BMC Public Health
Background The association between living alone and frailty has not been systematically investigated in previous studies, among which inconsistent results were yielded.
Yuanyuan Jiang, Wenbin Wu, Hengshuo Liu, Qi Zhou, Huan Xi   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Associations of living alone and loneliness with neuropsychiatric symptoms in individuals with mild cognitive impairment: A retrospective cross‐sectional study

PCN Reports
Aim Living alone and loneliness are recognized risk factors for neuropsychiatric symptoms in older adults. However, the distinct of the objective condition of living alone and subjective loneliness on specific neuropsychiatric symptoms in individuals ...
Kayo Takeda, Hideki Kanemoto, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Shigeki Katakami, Kenji Yoshiyama, Manabu Ikeda   +7 more
doaj   +1 more source

Influence of geographical residence on perceived community resilience between people of color and white individuals following Hurricane Harvey

Journal of Health Equity
Objective The objective of this study was to examine how individual-level factors (e.g., demographic variables) and community-level factors (e.g., median household income in the community, rates of residents living alone) are associated with perceived ...
Yuki Shigemoto
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Combined effect of living alone and osteoporosis status on the prevalence of depression in Chinese community-dwelling older population: a cross-sectional study

Frontiers in Public Health
BackgroundGiven the increasing burden of the “silent” depressive symptoms and the significant comorbidity of osteoporosis in the population living alone, this study aimed to investigate the separate and combined impacts of living alone and osteoporosis ...
Pingping Cai, Pingping Cai, Siqin Gaowa, Cheng Lin, Peipei Han, Peipei Han, Xiaoyu Chen, Xiaoyu Chen, Jinwen Zhang, Jinwen Zhang, Cheng Chen, Cheng Chen, Qianhao Wu, Qianhao Wu, Jingjie Miao, Jingjie Miao, Shumei Zhang, Lihua Li, Talin SarNa, Qi Guo, Qi Guo, Qi Guo   +21 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Time-varying living arrangements and suicide death in the general population sample: 14-year causal survival analysis via pooled logistic regression

Epidemiology and Psychiatric Sciences
Aims While past research suggested that living arrangements are associated with suicide death, no study has examined the impact of sustained living arrangements and the change in living arrangements. Also, previous survival analysis studies only reported
Z. Narita, T. Shinozaki, A. Goto, H. Hori, Y. Kim, H. C. Wilcox, M. Inoue, S. Tsugane, N. Sawada   +8 more
doaj   +1 more source