Results 161 to 170 of about 5,215 (215)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source
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Living Alone with Dementia

Dementia and Geriatric Cognitive Disorders, 1999
This report describes a population of individuals with dementia living alone in the community. Data were collected as part of the Canadian Study of Health and Aging (CSHA). We found that one third of the subjects in the CSHA sample with a dementia residing in the community lived alone.
E M, Ebly, D B, Hogan, K, Rockwood
openaire   +2 more sources

Living alone with dementia

Dementia, 2011
This paper details the findings of an exploratory study undertaken in 2009 into the older population who live alone with dementia, as part of a wider study into the phenomenon of living alone in older age with a cognitive impairment or early stage dementia.
Fleur, Duane   +2 more
openaire   +2 more sources

Living Alone

Clinical Gerontologist, 1997
The roles of performance-based activities of daily living and metacognition in return to independent living were evaluated in this preliminary study of geriatric rehabilitation patients. Importantly, all subjects were living entirely alone prior to admission to a medical rehabilitation facility.
Susan E. Macneill   +3 more
openaire   +1 more source

Living Alone, Consuming Alone?

2013
The previous chapter indicated variation in whether and how people living alone consciously express themselves through their home and showed that practices of ‘consuming’ the home often remember and display relationships to family and friends. This chapter extends the discussion through a focus on the consumption of food and holidays, topics that ...
Lynn Jamieson, Roona Simpson
openaire   +2 more sources

Living alone with dementia

British Journal of Nursing, 1994
Over the last few years, the two Home Alone motion pictures have made both a star and a millionaire of its main character actor Macauley Culkin. The success of the first film was constructed around a storyline of parental failing, abandonment and child vulnerability. As adults, we could identify and empathise with the home alone child as he struggled,
openaire   +2 more sources

The Future of Living Alone

2013
The number of people living alone is likely to continue to increase globally, both among the elderly and the working-age population, although it remains much more unthinkable and practically impossible in some regions of the world. In some parts of Europe and the United States, recession may cause pause and reversal, but, in general, where the trend ...
Lynn Jamieson, Roona Simpson
openaire   +2 more sources

Living Alone with Dementia

Dementia, 2003
As the number of people with dementia is increasing alongside the social trend of a greater proportion of the population living on their own, this article seeks to explore a number of issues arising from these circumstances. It summarizes a qualitative study of ten people with dementia who live alone in their own homes.
Gilmore, H., Gibson, F., Campbell, Jim
openaire   +1 more source

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