Results 151 to 160 of about 1,321,562 (288)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Diferenciais intra-urbanos no Município de Florianópolis, Santa Catarina, Brasil: potencial de uso para o planejamento em saúde

open access: yesCadernos de Saúde Pública
Partindo do pressuposto de que a ocupação espacial da população é um processo socialmente construído, e que o espaço social é determinante no processo saúde/doença, o presente estudo identificou e agrupou os setores homogêneos quanto à condição de vida ...
Josimari Telino de Lacerda   +2 more
doaj  

Life, gender, and work: Intersectional data on care work and the living conditions of women in Tumaco, Colombia. [PDF]

open access: yesData Brief
Escobar-Váquiro N   +4 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Um olhar sobre condições de vida: mortalidade de crianças e adolescentes residentes em Manguinhos, Rio de Janeiro, Brasil

open access: yesCadernos de Saúde Pública
Neste artigo são investigados, com base nos dados do Sistema de Informação de Mortalidade (SIM), os óbitos de crianças e adolescentes residentes em Manguinhos, no período 1996 a 2000, tendo como objetivo apurar suas principais características e ...
Marcelo Rasga Moreira   +2 more
doaj  

Navigating long-term patient-reported outcomes after colorectal cancer surgery in older adults: ostomy, nutritional status, and living conditions as determinants in a prospective cohort study. [PDF]

open access: yesInt J Colorectal Dis
Teraishi F   +10 more
europepmc   +1 more source

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