Results 191 to 200 of about 380,564 (310)

Usability assessment of an interactive health technology for kidney living donors: protocol for a prospective cross-sectional survey. [PDF]

BMJ Open, 2022
Ortiz F, Giunti G.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Comparison of Kidney Graft Function and Survival in an Emulated Trial With Living Donors and Brain-Dead Donors. [PDF]

Transpl Int
Savoye E, Santin G, Legeai C, Kerbaul F, Gaillard F, Pastural M.   +5 more
europepmc   +1 more source

Didactical characteristics of Dutch websites about kidney transplantation targeted for kidney patients and living donors: An exploratory study. [PDF]

PEC Innov, 2022
van Klaveren CW, de Jong PGM, Hendriks RA, Luk F, de Vries APJ, van der Boog PJM, Rabelink AJ, Reinders MEJ.   +7 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Understanding Risks and Our Responsibility to Living Donors.

J Am Soc Nephrol, 2021
Gill JS, Schold J, Kaplan B.
europepmc   +1 more source

Imaging evaluation of uterine arteries in potential living donors for uterus transplantation: a comparative study of MRA, CTA, and DSA. [PDF]

Eur Radiol, 2022
Leonhardt H, Thilander-Klang A, Båth J, Johannesson M, Kvarnström N, Dahm-Kähler P, Brännström M.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Assessing asymmetrical kidney function in living donors: a retrospective cohort study on CT metrics. [PDF]

BMC Nephrol
Sturman J, Fenton A, Hayat U, Jones R, Lipkin G.   +4 more
europepmc   +1 more source

Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors. [PDF]

Front Immunol, 2021
Yang B, Sylvius N, Luo J, Yang C, Da Z, Crotty C, Nicholson ML.   +6 more
europepmc   +1 more source