Results 251 to 260 of about 377,869 (311)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
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2022
Living donor kidney transplant rates vary across the world and this heterogeneity arises from the different socio-cultural environments and legislative rules in place to encourage the practice. In countries with an established deceased donor infrastructure, living kidney donor programs have complemented the national kidney allocations systems but ...
Kimenai, Diederik H.J.A.N. +1 more
openaire +1 more source
Living donor kidney transplant rates vary across the world and this heterogeneity arises from the different socio-cultural environments and legislative rules in place to encourage the practice. In countries with an established deceased donor infrastructure, living kidney donor programs have complemented the national kidney allocations systems but ...
Kimenai, Diederik H.J.A.N. +1 more
openaire +1 more source
Urology, 1975
Donor nephrectomy was performed on 39 living related renal donors. The preoperative evaluation, surgical technique, and postoperative follow-up are presented. Major or minor complications developed in 23 per cent of the patients and included acute myocardial infarction, brachial plexus injury, acute glomerulonephritis, ileus, pneumonia, and urinary ...
S C, Jacobs +3 more
openaire +2 more sources
Donor nephrectomy was performed on 39 living related renal donors. The preoperative evaluation, surgical technique, and postoperative follow-up are presented. Major or minor complications developed in 23 per cent of the patients and included acute myocardial infarction, brachial plexus injury, acute glomerulonephritis, ileus, pneumonia, and urinary ...
S C, Jacobs +3 more
openaire +2 more sources
Current Opinion in Urology, 1999
The need for more organs for kidney transplantation is increasing. Cadaver sources for these organs are stable, therefore living donation must increase if the need is to be met. Less perfect kidneys are now being transplanted. The pool of potential donors is being expanded.
S C, Jacobs +4 more
openaire +2 more sources
The need for more organs for kidney transplantation is increasing. Cadaver sources for these organs are stable, therefore living donation must increase if the need is to be met. Less perfect kidneys are now being transplanted. The pool of potential donors is being expanded.
S C, Jacobs +4 more
openaire +2 more sources
Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 2012
AbstractSix decades after its first implementation, kidney transplantation remains the optimal therapy for end‐stage renal disease requiring dialysis. Despite the incontrovertible mortality reduction and cost‐effectiveness of kidney transplantation, the greatest remaining barrier to treatment of end‐stage renal disease is organ availability.
Juan P, Rocca +2 more
openaire +2 more sources
AbstractSix decades after its first implementation, kidney transplantation remains the optimal therapy for end‐stage renal disease requiring dialysis. Despite the incontrovertible mortality reduction and cost‐effectiveness of kidney transplantation, the greatest remaining barrier to treatment of end‐stage renal disease is organ availability.
Juan P, Rocca +2 more
openaire +2 more sources
Transplantation, 2003
Abstract This chapter provides an historical perspective of living donor nephrectomy from the early days to current applications. The selection criteria for living donors, the various types of surgical approaches available, with particular reference to the laparoscopic technique, and the immediate and long-term results of these procedures, are ...
Peter J, Morris, And Anthony P, Monaco
openaire +2 more sources
Abstract This chapter provides an historical perspective of living donor nephrectomy from the early days to current applications. The selection criteria for living donors, the various types of surgical approaches available, with particular reference to the laparoscopic technique, and the immediate and long-term results of these procedures, are ...
Peter J, Morris, And Anthony P, Monaco
openaire +2 more sources