Results 101 to 110 of about 1,716,496 (303)

Innovation: The Living Laboratory Perspective

Computer-Aided Design and Applications, 2007
Innovation research is highly interdisciplinary and has attracted numerous science and practice communities. Though innovation results are broadly applicable, this paper focuses on engineering and service domains. The two are tightly interrelated, as the benefits of product innovation are realized through the business activities, and certain business ...
openaire   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Human-activity-centered measurement system:challenges from laboratory to the real environment in assistive gait wearable robotics [PDF]

, 2018
Assistive gait wearable robots (AGWR) have shown a great advancement in developing intelligent devices to assist human in their activities of daily living (ADLs).
Abouhossein, Alireza, Awad, Mohammed I., Bradley, David, Dehghani-Sanij, Abbas A., Martinez-Hernandez, Uriel   +4 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Cooperation, Competition, and Risk Attitudes: An Intergenerational Field and Laboratory Experiment [PDF]

The population of most developed societies is ‘graying'. As life expectancy increases and the large baby-boom generation approaches retirement age, this has critical consequences for maintaining a high standard of living and the sustainability of pension
Gary Charness, Marie-Claire Villeval
core  

Is there a lack of science resources and specialists for kaiako at Kura reo o Waikato? [PDF]

, 2010
The New Zealand debates on culture and science education for Maaori are grounded in the concern for the under-achievement of tauira in science. In 1995, a lack of subject experts, specialists and resources to implement the Ministry of Education’s science
Hopkins, Aareka
core  

A biophysical model of prokaryotic diversity in geothermal hot springs

, 2008
Recent field investigations of photosynthetic bacteria living in geothermal hot spring environments have revealed surprisingly complex ecosystems, with an unexpected level of genetic diversity.
A. J. Watson, A. L. Koch, Anna Klales, C. L. Lehman, D. de Beer, D. M. Ward, D. M. Ward, D. Tilman, Elizabeth Janus Nett, J. K. Kristjansson, J. M. Chase, James Duncan, M. J. Ferris, M. J. Ferris, M. J. Ferris, M. R. Droop, M. T. Madigan, R. F. Ramaley, R. W. Castenholz, S. C. Nold, S. M. Sievert, Suzanne Amador Kane, T. D. Brock, T. D. Brock   +23 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Enzyme-assisted nanopore sensor for sensitive and multiplexed detection of microRNAs

Journal of Nanobiotechnology
MicroRNAs (miRNAs) play crucial roles in the pathogenesis of diverse diseases; however, their extremely low abundance in complex biological systems makes highly sensitive and specific multiplexed detection particularly challenging.
Xiaobin Huang, Yakun Yi, Ke Zhou, Lei Liu, Hai-Chen Wu   +4 more
doaj   +1 more source

University campuses as living laboratories

Urbis et Orbis Microhistory and Semiotics of the City
The study explicates the methodology of living laboratories as open experiment spaces in real urban environment, which provide the development and testing of technological and social innovations in the city, contribute to the development of technological entrepreneurship and interdisciplinary communication, as well as strengthen emotional connection ...
N. B. Sedikova, E. I. Inozemtseva, N. V. Kakhaeva, D. V. Chernikova   +3 more
openaire   +1 more source