Results 111 to 120 of about 1,716,496 (303)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Growing Consolidation and Electric Vehicle Solutions in Urban Logistics [PDF]

, 2017
Presentation of the CITYLAB project trials and evaluations in London. Purpose is to demonstrate how to grow further existing sustainable urban freight solutions with a carrier's carrier approach to logistics business and a living laboratory approach to ...
Leonardi, J., Leonardi, J.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A nanofluidic oscillating neuron

Nature Communications
Nanofluidics provide a transformative platform for creating neuron emulates, yet replicating their complex spiking dynamics remains challenging. Herein, we report a nanofluidic oscillating neuron (FON) which could emulate spiking-form encoding functions ...
Tianyi Xiong, Xiulan He, Boyang Xie, Guangguo Guo, Yueru Zhao, Ying Liu, Cong Pan, Yanan Jiang, Wenjie Ma, Fei Wu, Ping Yu, Lanqun Mao   +11 more
doaj   +1 more source

In Vivo Photoelectrochemical Analysis

Chemosensors
Microelectrode-based photoelectrochemical (PEC) technology is a novel and rapidly developing analytical method for the in vivo probing of neurochemical events in the brain, which is distinguished by its low background noise and high detection sensitivity.
Li Li, Yueru Zhao, Cong Pan, Wenjie Ma, Ping Yu   +4 more
doaj   +1 more source

The Architecture of Communal Living: Lessons from Arcosanti in Arizona [PDF]

, 2001
Paolo Soleri's arcology model (architecture + ecology addresses issues of sustainability by advocating living in a balanced relationship between urban morphology and performance within dense, integrated and compact structures.
Grierson, David
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Conjugate Polymer Anchor Enhancing Matrix Vacuum Stability and Improving MALDI MSI via Ion Bond

Advanced Science
Poor vacuum stability limits the application of many matrices in matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) that requires long‐term measurement duration in high vacuum.
Xi Yu, Junyu Chen, Zhengzhou Li, Duo Shen, Huihui Liu, Zongxiu Nie   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Living Crayfish in the Laboratory

The American Biology Teacher, 1969
T he crayfish is one of the most interesting living creatures that can be studied in high school biology. It not only has a variety of fascinating habits, but it is very easily observed and maintained in the laboratory. All of our crayfish are brought in by students.
openaire   +1 more source