Results 151 to 160 of about 1,709,377 (255)

Prevalence and correlates of low-level viremia and viral load non-suppression among adults on HIV treatment: Results from the Tanzania HIV Impact Survey, 2022-2023. [PDF]

PLoS One
Sumba S, Kailembo A, Ismail A, Njau P, Wang A, Mchau G, Revocatus B, Taluka EA, Mayige M, Nkumbula T, Faki FH, Malewo O, Moremi N, Karugendo E, Issa F, Masemo A, Laws R, Patel D, Maruyama H, Kamwela J, El-Sadr W, Mgomella GS, Swaminathan M, Porter S, Khatib A.   +24 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

ECOLOOP SOIL Living laboratory description

The deliverable defines the implementation of ECOLOOP living lab as a co-innovation space, through participatory and transdisciplinary systemic processes. Related task T2.4.
openaire   +1 more source

Fatal granulomatous amoebic encephalitis due to Acanthamoeba sp. with bacterial co-infection in an immunocompetent critically ill patient: A case report and review of the literature. [PDF]

IDCases
Boukoub N, Amjoud H, Fahde S, ELKhayari M, ELHakkouni A, Hachimi A.   +5 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Rupture of a Hepatic Hemangioma in the Remnant Liver Following Hybrid Extended Left Hemihepatectomy in a Living Liver Donor: A Case Report. [PDF]

Surg Case Rep
Tsunoda R, Matsushima H, Soyama A, Kinoshita A, Migita K, Satoh A, Nakamura S, Kamehama F, Hamada T, Imamura H, Adachi T, Eguchi S.   +11 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Cryptococcosis in Colombia: Analysis of Data from Laboratory-Based Surveillance 2017-2024. [PDF]

J Fungi (Basel)
Lizarazo J, Agudelo CI, Escandón P, Castañeda E.   +3 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source