Results 171 to 180 of about 2,001,979 (250)

Editorial: Living Labs (March 2019)

Technology Innovation Management Review, 2019
Chris McPhee, Anna Ståhlbröst, Abdolrasoul Habibipour, Mari Runardotter, Diana Chronéer   +4 more
doaj   +1 more source

A roadmap for safe, regulation-compliant Living Labs for AI and digital health development. [PDF]

Sci Adv
Gilbert S, Mathias R, Schönfelder A, Wekenborg M, Steinigen-Fuchs J, Dillenseger A, Ziemssen T.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Letter to the Editor on "From Concept to Clinic: Living Labs and Regulatory Sandboxes for Health System Digitalization and the Integration of Innovative Devices Into Clinical Workflows". [PDF]

IEEE J Transl Eng Health Med
Mathias R, Schonfelder A, Welzel C, Gilbert S.   +3 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A comprehensive analysis of digital health-focused Living Labs: innovative approaches to dementia. [PDF]

Front Med (Lausanne)
Figueiredo T, Midão L, Carrilho J, Videira Henriques D, Alves S, Duarte N, Bessa MJ, Fidalgo JM, García M, Facal D, Felpete A, Filgueira IR, Carlos Bernárdez J, Rodríguez M, Costa E.   +14 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Transforming European Food Systems with multi-actor networks and Living Labs through the FoodSHIFT Approach. [PDF]

Open Res Eur
Schafer LJ, Anthouli A, Schmidt A, Beblek A, Fruehbeisser A, Walthall B, Mingolla C, Rogozan C, Petruzzella D, Wascher D, Volpe F, Ruggeri G, Arciniegas G, Vicente-Vicente JL, Riviou K, Valta K, Marijke Wenzel L, Labellarte L, Crivits M, Swiader M, Lysak M, Sylla M, Eyre P, Barbu R, Corsi S, Henriksen CB.   +25 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Living labs opened dialogues about antibiotic use in dairy cattle and pig sectors - Insights from a Danish case study based on participatory action research. [PDF]

Acta Vet Scand
Vaarst M, Studnitz M, Krogh MA, Kongsted H.   +3 more
europepmc   +1 more source