Results 71 to 80 of about 50,873 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

In-situ syntheses of graft copolymers by metal-free strategies: combination of photoATRP and ROP

Designed Monomers and Polymers, 2020
A completely metal-free and environmentally friendly strategy is demonstrated for the preparation of graft copolymers by combining photoinduced Atom Transfer Radical Polymerization (ATRP) and Ring Opening Polymerization (ROP).
Gorkem Yilmaz
doaj   +1 more source

Oriented arrangement of simple monomers enabled by confinement: towards living supramolecular polymerization

Nature Communications, 2021
Using simple monomers in living supramolecular polymerization is difficult due to energy principles. Here the authors use confinement from a layered double hydroxide nanomaterial to successfully polymerise several simple monomers with length control and ...
Yingtong Zong, Si-Min Xu, Wenying Shi, Chao Lu   +3 more
doaj   +1 more source

Living free-radical polymerization of styrene under a constant source of gamma radiation

, 2002
Living polymerization of styrene was observed using gamma radiation as a source of initiation and 1-phenylethyl phenyldithioacetate as a reversible addition-fragmentation chain transfer (RAFT) agent.
Davis, Thomas P., Quinn, JF, Barner, Leonie, Barner, L, Davis, TP, Rizzardo, E, Rizzardo, Ezio, Quinn, John F.   +7 more
core   +1 more source

Synthesis of controlled polymeric cross-linked coatings via iniferter polymerisation in the presence of tetraethyl thiuram disulphide chain terminator [PDF]

, 2010
A “grafting from” approach has been used for controlled deposition of cross- linked polymers by living radical polymerisation. Borosilicate glass was modified with N,N-diethylaminodithiocarbamoylpropyl(trimethoxy)silane, in order to confine the ...
Whitcombe M. J., Chianella, Iva, Chianella I., Sanchez I., Whitcombe, Michael J., Sanchez, I., BOSSI, Alessandra Maria, Uludag Y., Bossi, Alessandra, Fowler, S., Subrahmanyam, S., Piletsky, Sergey A., Uludag, Yildiz, Fowler S., Piletsky S. A., Subrahmanyam S.   +15 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Anionic polymerization of p-(2,2′-diphenylethyl)styrene and applications to graft copolymers

Designed Monomers and Polymers, 2017
Well-controlled anionic polymerization of an initiator-functionalized monomer, p-(2,2′-diphenylethyl)styrene (DPES), was achieved for the first time. The polymerization was performed in a mixed solvent of cyclohexane and tetrahydrofuran (THF) at 40 °C ...
Minglu Huang, Bingyong Han, Jianmin Lu, Wantai Yang, Zhifeng Fu   +4 more
doaj   +1 more source

Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights

, 2011
Among the class of zwitterionic polymers poly(carboxybetaine)s (poly(CB)s) are unique, emerging as the only ultra-low fouling materials known allowing the preparation of biosensors, fouling resistant nanoparticles, and non-adhesive surfaces for bacteria.
Brynda, Eduard, Eduard Brynda, Christopher Barner-Kowollik, Šubr, Vladimir, Schmidt, Bernhard V.K.J., Vladimir Šubr, Schmidt, B., Brynda, E., Barner-Kowollik, C., Rodriguez‐Emmenegger, Cesar, Sedlakova, Zdenka, Bologna Alles, Aldo, Bologna Alles, A., Rodriguez-Emmenegger, C., Alles, A. B., Schmidt, B. V. K. J., Zdenka Sedlakova, Sedlakova, Z., Barner‐Kowollik, Christopher, Bernhard V. K. J. Schmidt, Aldo Bologna Alles, Šubr, V., Cesar Rodriguez-Emmenegger   +22 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source