Results 191 to 200 of about 802,900 (310)

Impact of Smart Wearable Devices on Health and Health Inequality Among Older Adults: Evidence from China. [PDF]

Healthcare (Basel)
Wang X, Li Y, Lou W.
europepmc   +1 more source

Andrea Falcon, The Architecture of the Science of Living Beings. Aristotle and Theophrastus on Animals and Plants

David Lefebvre
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Anoxia-adapted cyanobacteria in a marine blue hole. [PDF]

Appl Environ Microbiol
Li Z, Zhang H, Wei T, He L, Wang Y.
europepmc   +1 more source

Living Language : Science & Society

, 2018
Mark Turin
openalex   +1 more source

Living Lattices - Merging Craft, Material Science, and Regenerative Design [PDF]

Namita Bhatnagar
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Editorial: Biomaterials, 3D printing technologies, and perspectives for bone and cartilage regeneration. [PDF]

Front Sports Act Living
Li J, Zhang X.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Living Lab Dementia: Mixed-methods process evaluation of a feasibility study of an academic-practice partnership in German long-term dementia care. [PDF]

BMC Geriatr
Bühler F, Leinen A, Bieber A, Köpke S, Meyer G, Seismann-Petersen S, Dichter MN.   +6 more
europepmc   +1 more source