Results 71 to 80 of about 819,588 (267)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The voice of evidence

eLife, 2018
In an era in which evidence is being disregarded, scientists need to speak up in support of the pursuit for truth.
Eve Marder
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enhancing Oxygen Evolution Catalysis by Tuning the Electronic Structure of NiFe-Layered Double Hydroxides Through Selenization

Nanomaterials
Electrocatalytic water splitting is a critical approach for achieving carbon neutrality, playing an essential role in clean energy conversion. However, the slow kinetics of the oxygen evolution reaction (OER) remains a major bottleneck hindering energy ...
Ze Wang, Yifang Liang, Taifu Fang, Xinyu Song, Luobai Yang, Liying Wen, Jinnong Wang, Dongye Zhao, Shifeng Wang   +8 more
doaj   +1 more source

SCIENCE FOR MODERN LIVING* [PDF]

School Science and Mathematics, 1953
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/72328/1/j.1949-8594.1953.tb06961.x ...
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Can eDNA Replace Trawl Surveys for Estuarine Species Distribution Modeling: Insights From Collichthys lucidus in the Yangtze River Estuary

Ecology and Evolution
Species distribution data underpin species distribution models (SDMs), which are essential for identifying habitat preferences and informing conservation strategies.
Xiaoyu Geng, Wei Tang, Jianhui Wu, Chunxia Gao, Xuefang Wang   +4 more
doaj   +1 more source

The haves and the have nots

eLife, 2013
As the equipment needed to perform state-of-the-art research in many areas of biology becomes ever more expensive, Eve Marder worries that researchers in less wealthy institutions might be left behind.
Eve Marder
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source