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Principles for the design of multicellular engineered living systems [PDF]

open access: goldAPL Bioeng, 2022
Onur Aydin   +16 more
openalex   +2 more sources

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

open access: yesNature Communications, 2021
Mitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both ...
Jerome Avellaneda   +6 more
doaj   +1 more source

Variability of Phenolic Compound Accumulation and Antioxidant Activity in Wild Plants of Some Rumex Species (Polygonaceae)

open access: yesAntioxidants, 2022
Today, more than ever, the search for non-trivial sources of biologically active substances is critical. Plants of the genus Rumex are noteworthy.
Pavel Feduraev   +10 more
doaj   +1 more source

Desmosomal connectomics of all somatic muscles in an annelid larva

open access: yeseLife, 2022
Cells form networks in animal tissues through synaptic, chemical, and adhesive links. Invertebrate muscle cells often connect to other cells through desmosomes, adhesive junctions anchored by intermediate filaments.
Sanja Jasek   +6 more
doaj   +1 more source

Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages

open access: yesNature Communications, 2023
Serotonin is a neurotransmitter that signals through 5-HT receptors to control key functions in the nervous system. Serotonin receptors are also ubiquitously expressed in various organs and have been detected in embryos of different organisms.
Sanjay Karki   +7 more
doaj   +1 more source

CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage

open access: yesNature Communications, 2021
New virions of Ff bacteriophages are extruded from the host cell via the channel built from phage protein pIV, homologous to bacterial secretins. Here, the authors report the structure of this channel from the f1 filamentous bacteriophage and propose its
Rebecca Conners   +9 more
doaj   +1 more source

CA1 pyramidal cell diversity is rooted in the time of neurogenesis

open access: yeseLife, 2021
Cellular diversity supports the computational capacity and flexibility of cortical circuits. Accordingly, principal neurons at the CA1 output node of the murine hippocampus are increasingly recognized as a heterogeneous population. Their genes, molecular
Davide Cavalieri   +7 more
doaj   +1 more source

In vitro reconstitution of branching microtubule nucleation

open access: yeseLife, 2020
Eukaryotic cell division requires the mitotic spindle, a microtubule (MT)-based structure which accurately aligns and segregates duplicated chromosomes.
Ammarah Tariq   +4 more
doaj   +1 more source

Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish

open access: yesNature Communications, 2023
The postural control mechanism in fish is unclear. Here, authors show that larval zebrafish recover upright posture after roll tilts by a body bend that produces corrective rotational torque. They also reveal the associated neural circuits and muscles.
Takumi Sugioka   +2 more
doaj   +1 more source

First Insight into the Diversity and Antibacterial Potential of Psychrophilic and Psychotrophic Microbial Communities of Abandoned Amber Quarry

open access: yesMicroorganisms, 2021
Natural habitats, including extreme ones, are potential sources of new antimicrobial compound producers, such as bacteriocins and enzymes, capable of degrading the matrix polysaccharides of bacterial biofilms. This study aimed to investigate biodiversity
Margarita Shevchenko   +8 more
doaj   +1 more source

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