Results 111 to 120 of about 3,258,483 (349)
Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
Nature Communications, 2018 The effects of mechanical forces, generated by actomyosin contractility, on E-cadherin based cell adhesion are poorly characterized in vivo. Here, the authors report that normal stress increases E-cadherin levels, whereas shear stress reduces E-Cadherin ...
Girish R. Kale +5 more
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Life Sustains Life 1. Value: Social and Ecological [PDF]
I would like to address the question of social and ecological value by bringing two approaches to this question into conversation with one another and show their connections. The two approaches are those of Jonathan Schell and Akeel Bilgrami.
Tully, James
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
The Localization Hypothesis and Machines [PDF]
, 2007 In a recent article in 'Artificial Life', Chu and Ho suggested that Rosen's central result about the simulability of living systems might be flawed. This argument was later declared ''null and void'' by Louie.
Chu, Dominique, Ho, W.
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Life Sustains Life 2. The ways of re-engagement with the living earth [PDF]
This article argues that we need to learn from the living earth how living systems sustain themselves and use this knowledge to transform our unsustainable and destructive social systems into sustainable and symbiotic systems within systems.
Tully, James
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Constructing a General Theory of Life: The Dynamics of Human and Non-human Systems [PDF]
The ultimate objective of theorists studying living systems is to construct a general theory of life that can explain and predict the dynamics of both human and nonhuman systems. Yet little progress has been made in this endeavour. Why?
Graeme Donald Snooks
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The Machine Conception of the Organism in Development and Evolution: A Critical Analysis [PDF]
, 2014 This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for ...
Nicholson, Daniel J.
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