Results 181 to 190 of about 3,258,483 (349)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The mechanism of generation of nerve impulse and its features of propagation along the nerve fiber cells in living systems [PDF]

, 2018
Pang Xiao Feng, Zeng Hong Juan, Josephine jiang, Ni Yin Jia   +3 more
openalex   +1 more source

Configurational fingerprints of multicellular living systems. [PDF]

Proc Natl Acad Sci U S A, 2021
Yang H, Pegoraro AF, Han Y, Tang W, Abeyaratne R, Bi D, Guo M.   +6 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Organs-on-chips: Advanced engineered living systems. [PDF]

APL Bioeng
Liu Y, Bian L.
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Retraction Note: Computerized Performance Monitoring Systems: Learning and Living with its Limitations [PDF]

, 2007
Daniel J. Luchins
openalex   +1 more source

Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria

, 2022
Pengchao Wang, Guangming Zhang, Zeling Xu, Zhe Chen, Xiaohong Liu, Chenyin Wang, Chaogu Zheng, Jiangyun Wang, Hongmin Zhang, Aixin Yan   +9 more
openalex   +1 more source

Fundamental constraints to the logic of living systems. [PDF]

Interface Focus
Solé R, Kempes CP, Corominas-Murtra B, De Domenico M, Kolchinsky A, Lachmann M, Libby E, Saavedra S, Smith E, Wolpert D.   +9 more
europepmc   +1 more source