Results 251 to 260 of about 3,258,483 (349)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Novel mycophenolic acid precursor-based fluorescent probe for intracellular H₂O₂ detection in living cells and Daphnia magna and Zebrafish model systems

Jongkeol An, Su Jeong Park, Neha Jain, Youngsam Kim, Satish Balasaheb Nimse, David G. Churchill   +5 more
openalex   +2 more sources

Correlates of retention on extended-release naltrexone among persons living with HIV infection transitioning to the community from the criminal justice system

, 2015
Sandra A. Springer, Frederick L. Altice, Shan-Estelle Brown, Angela Di Paola   +3 more
openalex   +1 more source

Onsager regression characterizes living systems in passive measurements

, 2022
Muenker TM, Knotz G, Krüger M, Betz T.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Large-scale tourism transformations through regeneration: A living systems perspective on tourism developments in Ukraine during the war

Kristof Tomej, Iana Bilynets
openalex   +1 more source

Activities of Daily Living of Patients with Malignant Brain Tumors Assessed By Using Functional Independence Measurement Scoring System

, 2015
Hiroshi Kanno Jo Sasame
openalex   +1 more source

Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications. [PDF]

Curr Opin Chem Biol
Price S, Que EL.
europepmc   +1 more source