Results 281 to 290 of about 3,258,483 (349)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Nature Chemical Biology, 2005
Dissecting complex cellular processes requires the ability to track biomolecules as they function within their native habitat. Although genetically encoded tags such as GFP are widely used to monitor discrete proteins, they can cause significant perturbations to a protein's structure and have no direct extension to other classes of biomolecules such as
Jennifer A, Prescher +1 more
openaire +2 more sources
Dissecting complex cellular processes requires the ability to track biomolecules as they function within their native habitat. Although genetically encoded tags such as GFP are widely used to monitor discrete proteins, they can cause significant perturbations to a protein's structure and have no direct extension to other classes of biomolecules such as
Jennifer A, Prescher +1 more
openaire +2 more sources
Electronics and Power, 1967
Control concepts are likely to give increasing insight into the functions and interrelationships in living creatures in both normal and abnormal states and may well influence clinical medicine and improve diagnosis and treatment of disease. Another aspect of our knowledge of control in living systems is the ability to integrate engineering devices with
openaire +1 more source
Control concepts are likely to give increasing insight into the functions and interrelationships in living creatures in both normal and abnormal states and may well influence clinical medicine and improve diagnosis and treatment of disease. Another aspect of our knowledge of control in living systems is the ability to integrate engineering devices with
openaire +1 more source
Living Systems and Non-Living Systems
Philosophy of Science, 1942Biology is in a unique position among the natural sciences. It is not simply complex physics and chemistry, for living organisms have a psychological as well as a physical side. Even as physical systems their character is highly special, largely because their material substance is continually changing; perhaps it was from them that Heraclitus derived ...
openaire +1 more source
How Live are Live Programming Systems?
Proceedings of the Programming Experience 2016 (PX/16) Workshop, 2016The idea of live programming has been applied in various domains, including the exploration of simulations, general-purpose application development, and even live performance of music. As a result, different qualitative definitions of the term live programming exist. Often, these definitions refer to a sense of "directness" or "immediacy" regarding the
Patrick Rein +3 more
openaire +1 more source