Results 21 to 30 of about 3,258,483 (349)

Cryo-electron microscopy of the f1 filamentous phage reveals insights into viral infection and assembly

open access: yesNature Communications, 2023
Phages are viruses that infect bacteria and dominate every ecosystem on our planet. As well as impacting microbial ecology, physiology and evolution, phages are exploited as tools in molecular biology and biotechnology.
Rebecca Conners   +6 more
doaj   +1 more source

True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors

open access: yesCell Reports, 2018
Summary: Signaling nanodomains rely on spatial organization of proteins to allow controlled intracellular signaling. Examples include calcium release sites of cardiomyocytes where ryanodine receptors (RyRs) are clustered with their molecular partners ...
Isuru Jayasinghe   +8 more
doaj   +1 more source

Probing active forces via a fluctuation-dissipation relation: Application to living cells [PDF]

open access: yes, 2013
We derive a new fluctuation-dissipation relation for non-equilibrium systems with long-term memory. We show how this relation allows one to access new experimental information regarding active forces in living cells that cannot otherwise be accessed. For
C. Maes   +10 more
core   +4 more sources

An archaellum filament composed of two alternating subunits

open access: yesNature Communications, 2022
The archaellum is a molecular machine used by archaea to swim, consisting of an intracellular motor that drives the rotation of an extracellular filament composed of multiple copies of proteins named archaellins.
Lavinia Gambelli   +7 more
doaj   +1 more source

A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics

open access: yesNature Communications, 2021
Actin polymerization provides force for vital processes of the eukaryotic cell, but our understanding of actin dynamics and energetics remains limited due to the lack of high-quality probes.
Jessica Colombo   +7 more
doaj   +1 more source

Analysis of Pneumocystis Transcription Factor Evolution and Implications for Biology and Lifestyle

open access: yesmBio, 2023
Pneumocystis jirovecii kills hundreds of thousands of immunocompromised patients each year. Yet many aspects of the biology of this obligate pathogen remain obscure because it is not possible to culture the fungus in vitro independently of its host ...
Ryan Ames   +3 more
doaj   +1 more source

An adaptive microscope for the imaging of biological surfaces

open access: yesLight: Science & Applications, 2021
A smart-scanning fluorescence microscope adapts its scanning scheme to the curved surface of embryonic cell sheets. This results in a considerable reduction in light dose without deterioration of the images.
Faris Abouakil   +5 more
doaj   +1 more source

Optoplasmonic characterisation of reversible disulfide interactions at single thiol sites in the attomolar regime

open access: yesNature Communications, 2020
Visualising single-molecule reactions, to understand their mechanisms, is a challenging task. Here, the authors investigate disulfide exchange reactions with thiolates immobilised on a gold nanoparticle through a label-free optoplasmonic sensor, and ...
Serge Vincent   +2 more
doaj   +1 more source

Epithelial disruption drives mesendoderm differentiation in human pluripotent stem cells by enabling TGF-β protein sensing

open access: yesNature Communications, 2023
Fate specification in the mammalian epiblast rely on complex interactions between morphogens and tissue organization. Here, the authors highlight epithelial integrity as a key determinant of TGF-β activity and a mechanism guiding morphogen sensing and ...
Thomas Legier   +6 more
doaj   +1 more source

The Content of Certain Groups of Phenolic Compounds and the Biological Activity of Extracts of Various Halophyte Parts of Spergularia marina (L.) Griseb. and Glaux maritima L. at Different Levels of Soil Salinization

open access: yesPlants, 2022
Halophyte plants are known for their resistance to harsh environmental conditions associated with excess salts in their habitats. Their resistance to salinization is due, among other things, to their high ability to detoxify free radicals, owing to the ...
Artem Pungin   +8 more
doaj   +1 more source

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