Results 91 to 100 of about 1,974,145 (268)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Leverkusen Memories (2010)

open access: yes, 2010
Leverkusen Memories was inspired by the Leverkusen Pieces (1969) by Robert Barry. Something that is taking shape in my mind and will sometimes come to consciousness. Something that is searching for me and needs me to reveal itself.
Living, Bernhard
core  

Evaluation of a Community-Based Advance Care Planning Campaign for a General Adult Population

open access: yesPalliative Medicine Reports
Background: Early advance care planning (ACP) has been widely recommended, but overall uptake remains low. Most efforts to improve formal ACP adoption, namely living will (LW) and health care agent (HCA) documentation, focus on medical settings targeted ...
Peiyuan Zhang   +4 more
doaj   +1 more source

Advanced directives: open issues

open access: yesItalian Journal of Medicine, 2013
BACKGROUND In Italy Advanced directives have not been regulated by law yet. Moreover, there is a confusion of concepts: advanced directives, refusal of treatment, medical futility and euthanasia are not synonymous.DISCUSSION The following aspects are ...
Gabriella Negrini
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Considering a Living Will

open access: yes, 2015
A living will is a written declaration informing medical personnel whether certain life-sustaining procedures should be withheld or withdrawn if (1) you are in a terminal condition; and (2) you are unable to decide for yourself.

core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Living Will

open access: yes, 2019
V današnjem času vsesplošnega razvoja medicine, ki podaljšuje življenje pacienta, je nujno zagotoviti institut, ki varuje avtonomijo vnaprej izražene volje pri sprejemanju odločitev v zvezi z lastno smrtjo.
Kozar, Ana
core  

Development of knowledge⁃attitude⁃practice(KAP) questionnaire on living will of elderly patients and its reliability and validity test

open access: yesHuli yanjiu, 2020
ObjectiveTo develop knowledge⁃attitude⁃practice(KAP) questionnaire on living will of elderly patients,and to test its reliability and validity.MethodsWith framework of knowledge⁃attitude⁃practice(KAP) theory,knowledge⁃attitude⁃practice(KAP) questionnaire
ZHANG Yanting, QIAN Xinyi, LI Jianjun
doaj  

Are we Living an Illusion? Folk Intuitions on the Problem of Free Will

open access: yesRivista Internazionale di Filosofia e Psicologia, 2015
In recent years, philosophy has witnessed the birth and development of a new research program that has provoked both enthusiasm and strong criticism: Experimental Philosophy (or X-Phi).
Silvia Felletti
doaj   +1 more source

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