Results 131 to 140 of about 5,745,733 (299)

The knowledge, the will and the power : a plan of action to meet the HIV prevention needs of Africans living in England [PDF]

open access: yes, 2008
The Knowledge, The Will and The Power is a statement of what we, the NAHIP Partners, plan to do to prevent HIV transmissions occurring during sexual activity among the diverse population of Africans living in England (Chapter 1). We describe the size and
Chaula, J.   +4 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Legal and Ethical Aspects of Discontinuing Futile Medical Care in Poland, the United Kingdom and Italy. A Comparative-Legal Perspective

open access: yesPrzegląd Prawniczy Uniwersytetu im. Adama Mickiewicza
Futile care encompasses a range of medical procedures that serve to sustain the vital functions of a terminally ill person, thus prolonging their dying process.
Oliwia Czajkowska, Natalia Robak
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Comparing the Impacts of Social Security Benefit Reductions on the Income Distribution of the Elderly [PDF]

open access: yes
Benefit reductions will likely be a part of the eventual Social Security reform in the United States. This research attempts to quantify the intragenerational and intergenerational impacts of different benefit reduction proposals on the incomes of the ...
Pfau, Wade Donald
core   +1 more source

Using simulations and artificial life algorithms to grow elements of construction [PDF]

open access: yes, 2006
'In nature, shape is cheaper than material', that is a common truth for most of the plants and other living organisms, even though they may not recognize that. In all living forms, shape is more or less directly linked to the influence of force, that was
Jaworski, P.L.
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

THE CAUSES AND CONSEQUENCES OF RURAL IMMIGRANT POPULATION GROWTH, 1950-1990 [PDF]

open access: yes
This study tests whether evidence supports the hypothesis that rural immigrant populations are more sensitive to relative returns to human capital and living costs will be more elastic than those of native-born citizens. An empirically tractable model of
Huang, Tzu-Ling   +2 more
core   +1 more source

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