Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni +5 more
wiley +1 more source
Correction to "Investigation of Electrostatic Effects on Enzyme Catalysis: Insights from Computational Simulations of Monoamine Oxidase A Pathological Variants Leading to the Brunner Syndrome". [PDF]
Rajić M, Stare J.
europepmc +1 more source
ABSTRACT Aims This cross‐sectional ‘case–control’ pilot study aimed to compare the size of periodontal wounds, periodontal status and total inflammatory burden between pregnant women with type 1 diabetes mellitus (T1DM) and non‐diabetic pregnant women. Methods Fifteen T1DM pregnant women and 15 healthy pregnant women were included. Clinical parameters (
M. Janc +4 more
wiley +1 more source
Prevalence of Oral Lichen Planus in Patients Referred to the Department of Oral Diseases and Periodontology in Ljubljana, Slovenia. [PDF]
Skaleric E +3 more
europepmc +1 more source
Task Complexity Effects on Writing Processes and Correlations With Text Features
ABSTRACT Research on task complexity (TC) effects on second language (L2) text features is abundant and has contributed critical insights. Comparatively, less is known about how L2 writers respond cognitively to diverse TC conditions or about potential effects of such processing activity on the characteristics of the texts produced.
Aitor Garcés‐Manzanera +4 more
wiley +1 more source
Correction: Two recurrent pathogenic/likely pathogenic variants in PALB2 account for half of PALB2 positive families in Slovenia. [PDF]
Mesarič VA +9 more
europepmc +1 more source
ABSTRACT Introduction Heparin‐induced thrombocytopenia (HIT) is a rare but potentially life‐threatening, immune‐mediated adverse reaction to heparin. PF4‐dependent immunoassays are sensitive screening tests, but they detect both platelet‐activating and nonactivating antibodies; therefore, positive results require interpretation in clinical context and,
Elvira Maličev +4 more
wiley +1 more source
Parallel screening strategies reveal distinct phenotypic and genotypic profiles of familial hypercholesterolemia in children and adults. [PDF]
Sikonja J +14 more
europepmc +1 more source
Evaluating Selection Strategies Based on Inbreeding Load via Simulation
ABSTRACT Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of selection.
Simona Antonios +5 more
wiley +1 more source

