Results 161 to 170 of about 1,352,600 (310)

Preliminary exploration of the role of CD8⁺ T cells in anti-PD-1 antibody-induced myocarditis in C57BL/6 mice with Lewis lung carcinoma. [PDF]

Biomed Rep
Chen H, Li F, Song J, Wang S, Xu H, Lyu R, Zhang H, Chen G, Wu X, Ding M.   +9 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth. [PDF]

Cancer Immunol Res
Santiago-Carvalho I, Francisco R, Macedo BG, Salgado CL, Stoll CR, Shao S, Beniwal A, Kwok T, Banuelos A, Cione MP, White E, Johnston TM, Leff CL, Silva Junior I, Carvalho de Souza F, Thant W, Pandya P, D'Império Lima MR, Fernandez-Bussy S, Abia-Trujillo D, Vu LH, Tran NL, Husta BC, Copland JA, Gounari F, Justilien V, Lancaster JN, Borges da Silva H.   +27 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Chemoradiotherapy-Integrated Tumor Cell-Derived Microparticles Mediate Tumor Eradication in Malignant Pleural Effusion. [PDF]

J Extracell Vesicles
Zhou M, Kong L, Zhong W, Wang Y, Yuan W, Liu X, Wang J, Su M, Zheng Y, Feng Z, Zhou Z, Deng Y, Wei W, Yang X, Hu Y, Wan C, Sheng Y, Sun Y, Yang K.   +18 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Ginsenoside Rh4 Triggers Ferroptosis in Lung Cancer: Targeting <i>KEAP1</i>/<i>NRF2</i>/<i>HO-1</i> and Remodeling Gut Microbiota for Butyrate-Mediated <i>ATF3</i> Activation. [PDF]

Int J Mol Sci
Zhu Q, Xu W, Yang G, Gao Y, Zhao Y, Zhao Z, Kang Y, Li S, Zhao L.   +8 more
europepmc   +1 more source

Applied Beams, LLC [PDF]

Microscopy Today, 2020
openaire   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia. [PDF]

Am J Physiol Cell Physiol
Counts BR, Bonetto A, Chan HL, Au ED, Jiang Y, Couch ME, Guttridge DC, Ostrowski MC, Koniaris LG, Zimmers TA.   +9 more
europepmc   +1 more source