Results 241 to 250 of about 1,395,480 (391)
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Extending the safe apnea window: preclinical evaluation of the Turbo® O₂ cap for hypoxia mitigation during difficult intubation. [PDF]
Goodwin RB, Salvino C, Benninger B.
europepmc +1 more source
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
Cardiac atrophy associated to cancer: new perspectives in signaling pathways. [PDF]
Lodeiro AC +9 more
europepmc +1 more source
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo +14 more
wiley +1 more source
Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer. [PDF]
Zheng Y +8 more
europepmc +1 more source
Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam +6 more
wiley +1 more source
Metabolic nanoblockers for synergistic cancer treatment through glutaminase inhibition and sonodynamic therapy. [PDF]
Zhao W +6 more
europepmc +1 more source

