Results 201 to 210 of about 6,749 (308)

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Longitudinal Analysis of Amyloid PET and Brain MRI for Predicting Conversion from Mild Cognitive Impairment to Alzheimer's Disease: Findings from the ADNI Cohort. [PDF]

Tomography
Kim DH.
europepmc   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Proposal for a Protocol and a Handmade Arduino-Based and Open Source Device for Measuring the Residual Charge of Alkaline Batteries in View of an Attempt to Recharge Them. [PDF]

Methods Protoc
Visco G, Sammartino MP, Marchetti A, Castrucci M, Tomassetti M.   +4 more
europepmc   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

An economic analysis of Chemo Mouthpiece^® versus supportive care for the reduction of oral mucositis incidence in patients receiving chemotherapy. [PDF]

J Comp Eff Res
Zuniga R, Dineen A, Velasquez R, Lee DD, Zara A, Zara A, Tattoli B, Bourque M, Jacobucci F.   +8 more
europepmc   +1 more source

Sustainable Plant‐Based Electrodes for Electrocatalytic Conversion of Small Molecules: From Biomass to Functional Electrodes

Exploration, EarlyView.
This review summarizes recent progress in plant‐based electrodes for small‐molecule electro‐conversion, focusing on synthesis strategies such as carbonization, hydrothermal processing, electrodeposition, and chemical vapor deposition. It highlights the structural features influencing porosity and conductivity, and discusses their applications in water ...
Ying Long, Zhijie Chen, Jiangzhou Xie, Jinliang Zhu, Wei Wei, Yi‐Ming Yan, Bing‐Jie Ni   +6 more
wiley   +1 more source

Power Converter Design for Pulsed Electric Field-Based Milk Processing: A Proof of Concept. [PDF]

Foods
Domínguez-Soberanes J, Ruiz-Martinez OF, Davalos Hernandez F.   +2 more
europepmc   +1 more source

Personalized Precision in Healthcare Payment Systems: Insights From a Real‐World Cancer Patients Cohort Study

Health Care Science, EarlyView.
We developed an effective prediction model for reasonably high hospitalization costs, using gastric cancer surgery patients as an example. Integrating this assessment into the healthcare payment system based on diagnosis‐related groups is expected to improve the individualization and precision of health insurance fund utilization.
Kan Xue, Hongrui Tian, Qi Wang, Yinkui Wang, Fei Shan, Yansui Yang, Miao Yu, Zhonghu He, Ziyu Li, Jiafu Ji   +9 more
wiley   +1 more source

A Comprehensive Review of Green Hydrogen Technology: Electrolysis Methods, Topologies and Control Strategies, Applications. [PDF]

Materials (Basel)
Abudureyimu A, Tuluhong A, Chang Q, Wang F, Luo B.   +4 more
europepmc   +1 more source