Results 221 to 230 of about 30,865 (351)

Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product

open access: yesProtein Science, Volume 35, Issue 3, March 2026.
Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo   +5 more
wiley   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

open access: yesPhytotherapy Research, Volume 40, Issue 3, Page 965-985, March 2026.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao   +13 more
wiley   +1 more source

Enzyme‐Powered DNA Origami Nanostructures for Enhanced Mucosal Diffusion

open access: yesSmall Structures, Volume 7, Issue 3, March 2026.
Single‐particle tracking reveals how DNA origami navigates mucus. Bare structures show limited diffusion, while enzyme‐functionalized nanostructures exhibit enhanced mobility. Symmetrically arranged urease creates uniform pH gradients for smooth propulsion, whereas asymmetrically placed catalase drives bubble‐mediated motion.
Matteo Tollemeto   +7 more
wiley   +1 more source

Laser Ablation Sampling With Low-Power Plasma: A LA-MIP-MS Instrument for Spaceflight. [PDF]

open access: yesRapid Commun Mass Spectrom
Farcy BJ   +11 more
europepmc   +1 more source

Separate and synergistic anti‐herbivore effects of non‐glandular trichomes and leaf chemistry in a desert plant

open access: yesFunctional Ecology, Volume 40, Issue 3, Page 736-749, March 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Plant defence phenotypes commonly integrate physical and chemical traits that may act synergistically against herbivores, but empirical evidence for synergy as a defence strategy remains limited.
Rosemary A. E. Glos   +2 more
wiley   +1 more source

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

open access: yesAddiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman   +15 more
wiley   +1 more source

Structural investigation of human U6 snRNA recognition by spliceosomal recycling factor SART3 RNA recognition motifs

open access: yesThe FEBS Journal, Volume 293, Issue 5, Page 1323-1340, March 2026.
Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim   +8 more
wiley   +1 more source

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