Results 371 to 380 of about 215,538 (386)
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Bone, 2020
Bone is a rigid and dynamic organ that continuously undergoes remodeling and repair. The balance between osteoblastic bone formation and osteoclastic bone resorption is essential for normal bone homeostasis. Osteoclasts are giant multinucleated cells derived from the monocyte/macrophage hematopoietic lineage and are regulated by various cytokines. Long
Yongyun Chang +5 more
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Bone is a rigid and dynamic organ that continuously undergoes remodeling and repair. The balance between osteoblastic bone formation and osteoclastic bone resorption is essential for normal bone homeostasis. Osteoclasts are giant multinucleated cells derived from the monocyte/macrophage hematopoietic lineage and are regulated by various cytokines. Long
Yongyun Chang +5 more
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Clinica Chimica Acta, 2019
Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Jin-yan Wang, Ai-qing Lu, Li-juan Chen
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Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Jin-yan Wang, Ai-qing Lu, Li-juan Chen
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LncRNA MALAT1 Promotes Ulcerative Colitis by Upregulating lncRNA ANRIL
Digestive Diseases and Sciences, 2020LncRNA MALAT1 contributes to the inflammatory responses induced by lipopolysaccharides (LPS), which shares similar pathogenesis with ulcerative colitis (UC), indicating the potential involvement of MALAT1 in UC.Expression of MALAT1 and lncRNA ANRIL in both UC patients and healthy controls was analyzed by RT-qPCR. ROC curve analysis was used to evaluate
Mingyan Zhu, Jian Xie
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WIREs RNA, 2016
The diversity of long non‐coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and evolution. The pervasive transcription of the largely non‐coding human genome makes the evolutionary age and conservation patterns of lncRNAs to a topic of interest.
Peter F. Stadler +2 more
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The diversity of long non‐coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and evolution. The pervasive transcription of the largely non‐coding human genome makes the evolutionary age and conservation patterns of lncRNAs to a topic of interest.
Peter F. Stadler +2 more
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LncRNAs and Available Databases
2021Long noncoding RNAs (lncRNAs) are involved in many regulatory mechanisms in practically every step of the RNA cycle, from transcription to RNA stability and translation. They are a highly heterogeneous class of molecules in terms of site of production, interaction networks, and functions. More and more databases are available on the web with the aim to
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Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
Nature reviews. Molecular cell biology, 2022Takayuki Nojima, N. Proudfoot
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2015
All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in ...
Alberto Valencia-Hipólito +1 more
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All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in ...
Alberto Valencia-Hipólito +1 more
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Science Signaling, 2015
The interaction of a lncRNA with the complex of NF-κB and its inhibitor IκB prevents phosphorylation-mediated release and activation of NF-κB.
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The interaction of a lncRNA with the complex of NF-κB and its inhibitor IκB prevents phosphorylation-mediated release and activation of NF-κB.
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Using Network Distance Analysis to Predict lncRNA–miRNA Interactions
Interdisciplinary Sciences Computational Life Sciences, 2021Li Zhang +4 more
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