Results 41 to 50 of about 985,064 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Modeling Sudden Ice Shedding from Conductor Bundles

, 2012
Sudden ice shedding from conductor bundles was modeled numerically and experimentally by improving the approaches proposed formerly for a single cable. The experimental study was carried out on a small-scale laboratory model of one span of a twin bundle.
Kollar, László E., Farzaneh, Masoud
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Intelligent Sensing and Control System for Real-Time Graded Load Shedding

Engineering Proceedings, 2023
A power shortage is a common case prevailing in today’s power scenario. Load shedding occurs when the demand power is greater than the generation power; then, the excessive load is cut to avoid power shortage.
Dhanasekar Ravikumar, Vijayaraja Loganathan, Kaushik Narayanan, Anandan Ravi sankar, Guru Sharan Muthu Govindasamy   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimal Electricity Load Interruption Based on Time Series Classification With Super Learner and Feature Filtering

IEEE Access
Load-shedding is vital for managing electrical power shortages and avoiding grid collapse. However, excessive electricity demand poses an imminent threat to the overall stability of power grid system (PGS) and its ability to run safely and reliably. Load-
Solomon Oluwole Akinola, Peter Olukanmi, Qing-Guo Wang, Tshilidzi Marwala   +3 more
doaj   +1 more source

Fairness of power system load-shedding plans [PDF]

, 2018
Transmission system operators apply selective load-shedding plans to prevent system wide interruptions and black-outs due to generation and transmission adequacy issues.
Ovaere, Marten, Evelyn Heylen, Heylen, Evelyn, Marten Ovaere, Dirk Van Hertem, Deconinck, Geert, Van Hertem, Dirk, Geert Deconinck   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Online Security Prediction and Control Framework for Modern Power Grids

Energies, 2021
The proliferation of renewable energy sources distributed generation (RES-DG) into the grid results in time-varying inertia constant. To ensure the security of the grid under varying inertia, techniques for fast security assessment are required.
Ifedayo Oladeji, Ramon Zamora, Tek Tjing Lie   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source