Results 211 to 220 of about 4,189,131 (315)

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan. [PDF]

Acta Neuropathol
Pascual JR, Rivera I, Nguyen H, Ngo PT, Hoang A, Andrews EJ, Rouanet J, Wright ST, Sordo L, Kofler J, Ikonomovic MD, Lai F, Mapstone M, Christian BT, Handen BL, Lott IT, Doran E, Hom CL, Harp J, Schmitt F, Tudorascu DL, Ances BM, Phelan M, Liu L, Flores-Aguilar L, Head E, Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators.   +26 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

In vivo kinematics of knee joint cartilage and meniscus contact areas under load application: a biomechanical MRI study. [PDF]

Arch Orthop Trauma Surg
Mayr MF, Meine H, Lange T, Yilmaz T, Taghizadeh E, Schmal H, Izadpanah K.   +6 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

MTMF-Grid: A multi-task multi-modal fusion model for operational forecasting and decision support in power grids. [PDF]

PLoS One
Zhang D, Shen B, Li P, Wang P, Sheng Y, Bing Y.   +5 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi-scale fusion transformer for EV charging station load prediction. [PDF]

Sci Rep
Liu W, Qiao J, Wang W, Zhao X.
europepmc   +1 more source