Results 61 to 70 of about 4,189,131 (315)
HeliyonThe development of resistance to chemotherapy in esophageal cancer represents a significant challenge in cancer treatment. Therefore, our study aimed to identify effective therapeutic strategies by examining the molecules involved in this chemoresistance.
Jindan Kai +4 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
, 2010 This concise and clearly focused Dictionary, with contributions by the leading authorities in their fields, brings order and clarity to a topic that can suffer from confusion over terminology and concepts.
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Load flow, short circuit and motor starting studies in electrical power substations.
ITEGAM-JETIAPower system studies are essential for the proper planning and design of electrical power substations. This paper presents the load flow, short circuit, and motor starting studies for 33/6.6/0.44 kV electrical power substation.
Mohan Muniappan
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
RESEARCH OF WHEEL-RAIL WEAR DUE TO NON-SYMMETRICAL LOADING OF A FLAT CAR
Nauka ta progres transportu, 2019 Purpose. The paper is aimed at determining the influence of non-symmetrical loading of a flat car on the magnitude of the wear factor of a wheel-rail pair when changing the operation parameters that occur in operation. Methodology. The dynamic loading of
O. V. Shatunov +3 more
doaj +1 more source
Method for calculating a two-drum mine winder
Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2020 In the Republic of Belarus, on the base of JSC “Soligorsk Institute for Resources Saving Problems with Pilot Production”, the development and launch of import-substituting mass production of large-capacity double-drum mine winders with an increased ...
V. Ya. Prushak, A. P. Dvornik
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