Results 61 to 70 of about 1,670,871 (318)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Evaluating Vacuum and Steam Heat to Eliminate Pinewood Nematodes in Naturally Infested Whole Pine Logs

Journal of Nematology
Pinewood nematodes threaten forest health and continue to interfere with international trade because they can be spread around the globe via nematode-infested wood.
Eisenback J. D., Chen Z., White M.
doaj   +1 more source

High-Speed and Low-Load Twin-Roll Casting of Al–5%Mg Strip [PDF]

, 2022
Kazuki Yamazaki, Toshio Haga
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The friction behavior and wear mechanism of RV reducer gear steel (20CrMo) subjected to three different heat treatment processes from −20 °C to 100 °C

Journal of Materials Research and Technology
The gear friction pairs in RV reducer always withstand a broad range of temperature, sliding velocity and heavy load. In the research, three types of heat treatment methods (carburizing + quenching, nitrocarburizing and high concentration ...
Jian Guan, Daqi Wu, Liuming Zhang, Gang Wang, Wenjie Chen, Wenjie Lin, Hui Zhao, Pengpeng Bai, Yu Tian, Wei Song   +9 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Participation in and use of skills development for work ability and expected retirement age: a cross-sectional study among senior workers

Frontiers in Public Health
IntroductionEurope’s aging population calls for ways to prolong working life. Skills development initiatives could potentially improve work ability and extend working lives and may thus be key to address this challenge.
Karina Glies Vincents Seeberg, Karina Glies Vincents Seeberg, Sebastian Venge Skovlund, Sebastian Venge Skovlund, Emil Sundstrup, Ole Steen Mortensen, Ole Steen Mortensen, Lars Louis Andersen, Lars Louis Andersen   +8 more
doaj   +1 more source

Failure mechanisms of bolted flanges in aero-engine casings subjected to impact loading

, 2021
Zhenzhong Cao, Fan Zhang, Dingguo Zhang, Yi-Hsiang Yu, Liang Li, Xian Guo   +5 more
openalex   +1 more source