Results 51 to 60 of about 12,622 (296)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Adaptive feedforward control design for gust loads alleviation and LCO suppression
, 2014 An adaptive feedforward controller is designed for gust loads alleviation and limit cycle oscillations suppression. Two sets of basis functions, based on the finite impulse response and modified finite impulse response approaches, are investigated to ...
Wang, Yongzhi +6 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Robust Control Synthesis for Gust Load Alleviation from Large Aeroelastic Models with Relaxation of Spatial Discretisation [PDF]
, 2012 04/03/14 meb. Ok to add, authors retain copyright.This paper introduces a methodology for the design of gust load control systems directly from large aeroelastic models with relaxation of spatial discretisation. A convenient state-space representation of
Ng, BF +3 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Global aero-structural design optimization of composite wings with active manoeuvre load alleviation [PDF]
, 2022 In the scope of the DLR project VicToria (Virtual Aircraft Technology Integration Platform), an integrated process for aero-structural wing optimization based on high fidelity simulation methods is continuously developed and applied.
Schuster, Andreas +3 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Aero-elastic wind turbine design with active flaps for AEP maximization [PDF]
Wind Energy Science, 2018 In optimal wind turbine design, there is a compromise between maximizing the energy producing forces and minimizing the absolute peak loads carried by the structures.
M. K. McWilliam +3 more
doaj +1 more source
Gust Load Alleviation of Flexible Composite Wing
CFD Letters, 2020 Gust load due to atmospheric turbulence is mandatory to be considered in aircraft analysis as part of airworthiness requirement. This safety related issue becomes more relevant recently in relation to the global warming that induces more frequent and extreme atmospheric disturbances encountered during air transportation.
Mohamed Ibren +4 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source