Results 111 to 120 of about 3,943,525 (296)
Spatial Load-bearing Characteristics of Four-pillar Chock-shield Support
工程科学与技术, 2020 The load-bearing body theory is proposed to analyze the full-range spatial load-bearing characteristics of four-pillar chock-shield support top beam, as the traditional load-bearing area theory based on the plane force system fails in this case.
Shengrong XIE +5 more
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
工程科学与技术, 2020 The numerical simulation is mostly employed in the existing studies of micro-texture. Compared with the numerical solution, the analytical solution describes more clearly the influence of main factors on the lubrication performances and the potential ...
Hua JI +4 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Applying a Capacity-Results Framework in Lao PDR and Other Pilot Countries
, 2005 Achieving the Millennium Development Goals (MDG) and poverty reduction objectives of developing countries requires a substantially greater investment in capacity development. This translates into action at three
Hart-Poliquin, Moira +1 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
WIM (Weigh In Motion), Load capacity and Bridge Performance [PDF]
, 2010 The continuous ageing and subsequent structural deterioration of a large number of existing structures make essential the development of efficient SHM systems (Structural Health Monitoring). The state of the health of structures is conditioned by several
Clemente p., De Stefano A.
core +1 more source