Results 261 to 270 of about 1,578,755 (350)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Stream channel storage: Closing the watershed total phosphorus budget. [PDF]

J Environ Qual
Beck WJ, Kovar JL, Isenhart TM, Moore PL, Rahutomo S, Schilling KE, Schultz RC, Thompson ML, Wolter CF, Streeter MT, Cole KJ, Tomer MD.   +11 more
europepmc   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

German version of subjective methods for measuring activation, mental workload, and attention in control rooms. [PDF]

Front Psychol
Rey-Becerra E, Tegtmeier P, Hartwig M, Wischniewski S.   +3 more
europepmc   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

The genomic impact of population connectivity and decline in Africa's elephants. [PDF]

Nat Commun
Pečnerová P, Ishida Y, Garcia-Erill G, Bertola LD, Santander CG, Liu X, Brüniche-Olsen A, Khan A, Hennelly LM, Balboa RF, Lin L, Rasmussen MS, Wang X, Schubert M, Al-Chaer A, Urbaniak S, Nobuta K, Treadup S, Viaud-Martinez KA, de Flamingh A, Malhi RS, Bird S, Ting N, Watsa M, Tchamba MN, Bourgeois S, Thouless C, Douglas-Hamilton I, Wittemyer G, Van Coeverden de Groot PJ, Muwanika VB, Masembe C, Georgiadis NJ, Hvilsom C, Heller R, Siegismund HR, Roca AL.   +36 more
europepmc   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

A do-it-yourself water quality sensor network to elucidate contaminant signatures and improve land management advice. [PDF]

Sci Rep
Dare JE, Özkundakci D, McDowell RW.
europepmc   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

An integrated physics-guided machine learning approach for predicting asphalt concrete fracture parameters. [PDF]

Sci Rep
Elahi M, Khan R, Mabood T, Khan MS, Ahmed A, Ahmad M, Tóth Z.   +6 more
europepmc   +1 more source